biostudies-literatureSaccon EVetenskapsrådet (VR)VetenskapsrådetKarolinska InstitutetUniversity of Missouri (MU)Karolinska Institutet (KI)University of Missourie0054921https://www.ebi.ac.uk/biostudies/studies/S-EPMC8565516biostudies-literatureUnknown9(2)In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to othersMicrobiology spectrumDistinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.PMC85655162017-013302020-01554Blasi FAliberti SDe Roberto PCostantino GLorson CLNeogi UBilli FValenti LSaccon EGabriel EEPeyvandi FSachs MCBandera AKrishnan SBaldini LScudeller LSingh KLashari AACanetta CFracchiolla NSGori ASciume MCOVID-19 Network Working Group,Mikaeloff FfalseDistinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others2021-01-01T00:00:00Z2021 Oct2025-06-01T01:59:02.602Z2025-06-01T01:59:02.602ZS-EPMC85655163446818510.1128/Spectrum.00549-21