{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["NIGMS NIH HHS","National Science Foundation"],"pagination":["1959-1973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8568667"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["232(5)"],"pubmed_abstract":["MicroRNAs (miRNAs) are essential regulators of gene expression in metazoans and plants. In plants, most miRNAs are generated from primary miRNA transcripts (pri-miRNAs), which are processed by the Dicer-like 1 (DCL1) complex along with accessory proteins. Serrate-Associated Protein 1 (SEAP1), a conserved splicing-related protein, has been studied in human and yeast. However, the functions of SEAP1 in plants remain elusive. Lack of SEAP1 results in embryo lethality and knockdown of SEAP1 by an artificial miRNA (amiR<sup>SEAP1</sup> ) causes pleiotropic developmental defects and reduction in miRNA accumulation. SEAP1 associates with the DCL1 complex, and may promote the interaction of the DCL1 complexes with pri-miRNAs. SEAP1 also enhances pri-miRNA accumulation, but does not affect pri-miRN"],"journal":["The New phytologist"],"pubmed_title":["Serrate-Associated Protein 1, a splicing-related protein, promotes miRNA biogenesis in Arabidopsis."],"pmcid":["PMC8568667"],"funding_grant_id":["OIA‐1557417","R01 GM127414","MCB‐1818082"],"pubmed_authors":["Yang W","Liu K","Li S","Yu B","Gan L","Zhou B","Zhang C","Li M","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"Serrate-Associated Protein 1, a splicing-related protein, promotes miRNA biogenesis in Arabidopsis.","description":"MicroRNAs (miRNAs) are essential regulators of gene expression in metazoans and plants. In plants, most miRNAs are generated from primary miRNA transcripts (pri-miRNAs), which are processed by the Dicer-like 1 (DCL1) complex along with accessory proteins. Serrate-Associated Protein 1 (SEAP1), a conserved splicing-related protein, has been studied in human and yeast. However, the functions of SEAP1 in plants remain elusive. Lack of SEAP1 results in embryo lethality and knockdown of SEAP1 by an artificial miRNA (amiR<sup>SEAP1</sup> ) causes pleiotropic developmental defects and reduction in miRNA accumulation. SEAP1 associates with the DCL1 complex, and may promote the interaction of the DCL1 complexes with pri-miRNAs. SEAP1 also enhances pri-miRNA accumulation, but does not affect pri-miRN","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T09:44:13.044Z","creation":"2025-04-05T09:44:13.044Z"},"accession":"S-EPMC8568667","cross_references":{"pubmed":["34449907"],"doi":["10.1111/nph.17691"]}}