{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Yin Z"],"pubmed_abstract":["Acute myeloid leukemia (AML) represents a frequently occurring adulthood acute leukemia (AL). Great progresses have been achieved in the treatment of AML, but its pathogenic mechanism remains unclear. This study reported the biological functions of lncRNA <i>DUBR</i> in AML pathogenic mechanism. As a result, lncRNA <i>DUBR</i> showed high expression level within AML, resulting in poor prognosis, especially in M4 AML. <i>In vitro</i> studies elucidated that knockdown of <i>DUBR</i> with small interfering RNA (siRNA) resulted in the suppression of survival and colony formation ability, as well as induction of apoptosis, in AML cells. RNA pull-down assay and computational revealed that <i>DUBR</i> could sponge with miRNA-142-3P and interact with FUS protein. MiRNA-142-3P have a negative corre"],"journal":["Frontiers in molecular biosciences"],"pagination":["754936"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8570042"],"repository":["biostudies-literature"],"pubmed_title":["MiRNA-142-3P and FUS can be Sponged by Long Noncoding RNA <i>DUBR</i> to Promote Cell Proliferation in Acute Myeloid Leukemia."],"pmcid":["PMC8570042"],"pubmed_authors":["Gu CM","Huang J","Zhu Y","Liu S","Shen H","Zhang MQ","Wu F","Zhang Q","Yin Z","Liu Z","Zhong Q","Huang Y","Ou R"],"additional_accession":[]},"is_claimable":false,"name":"MiRNA-142-3P and FUS can be Sponged by Long Noncoding RNA <i>DUBR</i> to Promote Cell Proliferation in Acute Myeloid Leukemia.","description":"Acute myeloid leukemia (AML) represents a frequently occurring adulthood acute leukemia (AL). Great progresses have been achieved in the treatment of AML, but its pathogenic mechanism remains unclear. This study reported the biological functions of lncRNA <i>DUBR</i> in AML pathogenic mechanism. As a result, lncRNA <i>DUBR</i> showed high expression level within AML, resulting in poor prognosis, especially in M4 AML. <i>In vitro</i> studies elucidated that knockdown of <i>DUBR</i> with small interfering RNA (siRNA) resulted in the suppression of survival and colony formation ability, as well as induction of apoptosis, in AML cells. RNA pull-down assay and computational revealed that <i>DUBR</i> could sponge with miRNA-142-3P and interact with FUS protein. MiRNA-142-3P have a negative corre","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T08:33:21.782Z","creation":"2022-02-11T12:37:42.374Z"},"accession":"S-EPMC8570042","cross_references":{"pubmed":["34746238"],"doi":["10.3389/fmolb.2021.754936"]}}