biostudies-literatureUnknown8Yin ZAcute myeloid leukemia (AML) represents a frequently occurring adulthood acute leukemia (AL). Great progresses have been achieved in the treatment of AML, but its pathogenic mechanism remains unclear. This study reported the biological functions of lncRNA <i>DUBR</i> in AML pathogenic mechanism. As a result, lncRNA <i>DUBR</i> showed high expression level within AML, resulting in poor prognosis, especially in M4 AML. <i>In vitro</i> studies elucidated that knockdown of <i>DUBR</i> with small interfering RNA (siRNA) resulted in the suppression of survival and colony formation ability, as well as induction of apoptosis, in AML cells. RNA pull-down assay and computational revealed that <i>DUBR</i> could sponge with miRNA-142-3P and interact with FUS protein. MiRNA-142-3P have a negative correFrontiers in molecular biosciences754936https://www.ebi.ac.uk/biostudies/studies/S-EPMC8570042biostudies-literatureMiRNA-142-3P and FUS can be Sponged by Long Noncoding RNA <i>DUBR</i> to Promote Cell Proliferation in Acute Myeloid Leukemia.PMC8570042Gu CMHuang JZhu YLiu SShen HZhang MQWu FZhang QYin ZLiu ZZhong QHuang YOu RfalseMiRNA-142-3P and FUS can be Sponged by Long Noncoding RNA <i>DUBR</i> to Promote Cell Proliferation in Acute Myeloid Leukemia.Acute myeloid leukemia (AML) represents a frequently occurring adulthood acute leukemia (AL). Great progresses have been achieved in the treatment of AML, but its pathogenic mechanism remains unclear. This study reported the biological functions of lncRNA <i>DUBR</i> in AML pathogenic mechanism. As a result, lncRNA <i>DUBR</i> showed high expression level within AML, resulting in poor prognosis, especially in M4 AML. <i>In vitro</i> studies elucidated that knockdown of <i>DUBR</i> with small interfering RNA (siRNA) resulted in the suppression of survival and colony formation ability, as well as induction of apoptosis, in AML cells. RNA pull-down assay and computational revealed that <i>DUBR</i> could sponge with miRNA-142-3P and interact with FUS protein. MiRNA-142-3P have a negative corre2021-01-01T00:00:00Z20212025-04-04T08:33:21.782Z2022-02-11T12:37:42.374ZS-EPMC85700423474623810.3389/fmolb.2021.754936