{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Z"],"funding":["Division of Chemistry","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["3473-3477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8570583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(6)"],"pubmed_abstract":["The regioselective amination and cross-coupling of a range of nucleophiles with allyl alcohols has been enabled by a dual catalytic strategy. This approach entails the combined action of an Ir photocatalyst that enables mild access to N-radicals via an energy transfer mechanism, as well as a Cu complex that intercepts the ensuing alkyl radical upon cyclization. Merger of this Cu-catalyzed cross-coupling enables a broad range of nucleophiles (e.g. CN, SCN, N<sub>3</sub>, vinyl, allyl) to engage in radical amino-functionalizations of olefins. Notably, stereo, regio, and kinetic probes provide insights into the nature of this Cu-based radical interception."],"journal":["ACS catalysis"],"pubmed_title":["Regioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling."],"pmcid":["PMC8570583"],"funding_grant_id":["CAREER 1654656","R35 GM119812"],"pubmed_authors":["Ngo DT","Zhang Z","Nagib DA"],"additional_accession":[]},"is_claimable":false,"name":"Regioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling.","description":"The regioselective amination and cross-coupling of a range of nucleophiles with allyl alcohols has been enabled by a dual catalytic strategy. This approach entails the combined action of an Ir photocatalyst that enables mild access to N-radicals via an energy transfer mechanism, as well as a Cu complex that intercepts the ensuing alkyl radical upon cyclization. Merger of this Cu-catalyzed cross-coupling enables a broad range of nucleophiles (e.g. CN, SCN, N<sub>3</sub>, vinyl, allyl) to engage in radical amino-functionalizations of olefins. Notably, stereo, regio, and kinetic probes provide insights into the nature of this Cu-based radical interception.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-05T14:05:28.058Z","creation":"2025-04-05T14:05:28.058Z"},"accession":"S-EPMC8570583","cross_references":{"pubmed":["34745713"],"doi":["10.1021/acscatal.1c00404"]}}