biostudies-literatureZhang ZDivision of ChemistryNational Institute of General Medical SciencesNIGMS NIH HHS3473-3477https://www.ebi.ac.uk/biostudies/studies/S-EPMC8570583biostudies-literatureUnknown11(6)The regioselective amination and cross-coupling of a range of nucleophiles with allyl alcohols has been enabled by a dual catalytic strategy. This approach entails the combined action of an Ir photocatalyst that enables mild access to N-radicals via an energy transfer mechanism, as well as a Cu complex that intercepts the ensuing alkyl radical upon cyclization. Merger of this Cu-catalyzed cross-coupling enables a broad range of nucleophiles (e.g. CN, SCN, N₃, vinyl, allyl) to engage in radical amino-functionalizations of olefins. Notably, stereo, regio, and kinetic probes provide insights into the nature of this Cu-based radical interception.ACS catalysisRegioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling.PMC8570583CAREER 1654656R35 GM119812Ngo DTZhang ZNagib DAfalseRegioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling.The regioselective amination and cross-coupling of a range of nucleophiles with allyl alcohols has been enabled by a dual catalytic strategy. This approach entails the combined action of an Ir photocatalyst that enables mild access to N-radicals via an energy transfer mechanism, as well as a Cu complex that intercepts the ensuing alkyl radical upon cyclization. Merger of this Cu-catalyzed cross-coupling enables a broad range of nucleophiles (e.g. CN, SCN, N₃, vinyl, allyl) to engage in radical amino-functionalizations of olefins. Notably, stereo, regio, and kinetic probes provide insights into the nature of this Cu-based radical interception.2021-01-01T00:00:00Z2021 Mar2025-04-05T14:05:28.058Z2025-04-05T14:05:28.058ZS-EPMC85705833474571310.1021/acscatal.1c00404