{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stone K"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["2361-2369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8570989"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(12)"],"pubmed_abstract":["<h4>Background</h4>Aortic arterial stiffness is a strong independent predictor of cardiovascular disease (CVD); however, its dependence on mean arterial pressure (MAP) limits its clinical utility. The aortic-femoral arterial stiffness gradient (af-SG), a novel marker of CVD risk, may be a promising alternative, but its dependence on MAP is not known. The aim of this study was to determine the relationship between MAP and the af-SG in healthy older adults and those with established disease, including hypertension and diabetes.<h4>Method</h4>We evaluated the dependency of the af-SG on MAP in healthy older adults (n = 694, aged 74 ± 5 years), and adults with hypertension (n = 2040, aged 76 ± 5 years), and diabetes (n = 1405, aged 75 ± 5 years) as part of the community-based Atherosclerosis Risk in Communities (ARIC) Study. Carotid-femoral pulse-wave velocity (cfPWV), femoral-ankle PWV (faPWV) and blood pressure were measured using standardized protocols. The af-SG was calculated as faPWV divided by cfPWV. Multivariable regression analysis was performed to test the independent association of MAP with af-SG, with adjustments for known confounders, including age, sex, BMI, blood glucose and heart rate.<h4>Results</h4>There was no significant relationship between the af-SG and MAP in healthy (β = 0.002, P = 0.301), hypertension (β = -0.001, P = 0.298) or diabetes (β = -0.001, P = 0.063) population groups, with MAP explaining less than 0.1, less than 0.1 and 0.2% of the variance in the af-SG, respectively.<h4>Conclusion</h4>These findings suggest that the af-SG may be regarded as a MAP independent index of arterial health and CVD risk in older adults."],"journal":["Journal of hypertension"],"pubmed_title":["The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults: the atherosclerosis risk in communities (ARIC) study."],"pmcid":["PMC8570989"],"funding_grant_id":["HHSN268201700003I","HHSN268201700004I","HHSN268201700005I","HHSN268201700001I","HHSN268201700002I","HHSN268201700005C","HHSN268201100006C","HHSN268201100005C","HHSN268201700001C","HHSN268201100008C","R01 AG053938","HHSN268201100007C","HHSN268201700002C","HHSN268201700003C","HHSN268201700004C","HHSN268201100011C","HHSN268201100010C","HHSN268201100012C"],"pubmed_authors":["Zieff G","Tanaka H","Paterson C","Stoner L","Stone K","Fryer S","Hughes TM","Meyer ML","Faulkner J","Heffernan K","Kucharska-Newton A","Matsushita K"],"additional_accession":[]},"is_claimable":false,"name":"The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults: the atherosclerosis risk in communities (ARIC) study.","description":"<h4>Background</h4>Aortic arterial stiffness is a strong independent predictor of cardiovascular disease (CVD); however, its dependence on mean arterial pressure (MAP) limits its clinical utility. The aortic-femoral arterial stiffness gradient (af-SG), a novel marker of CVD risk, may be a promising alternative, but its dependence on MAP is not known. The aim of this study was to determine the relationship between MAP and the af-SG in healthy older adults and those with established disease, including hypertension and diabetes.<h4>Method</h4>We evaluated the dependency of the af-SG on MAP in healthy older adults (n = 694, aged 74 ± 5 years), and adults with hypertension (n = 2040, aged 76 ± 5 years), and diabetes (n = 1405, aged 75 ± 5 years) as part of the community-based Atherosclerosis Risk in Communities (ARIC) Study. Carotid-femoral pulse-wave velocity (cfPWV), femoral-ankle PWV (faPWV) and blood pressure were measured using standardized protocols. The af-SG was calculated as faPWV divided by cfPWV. Multivariable regression analysis was performed to test the independent association of MAP with af-SG, with adjustments for known confounders, including age, sex, BMI, blood glucose and heart rate.<h4>Results</h4>There was no significant relationship between the af-SG and MAP in healthy (β = 0.002, P = 0.301), hypertension (β = -0.001, P = 0.298) or diabetes (β = -0.001, P = 0.063) population groups, with MAP explaining less than 0.1, less than 0.1 and 0.2% of the variance in the af-SG, respectively.<h4>Conclusion</h4>These findings suggest that the af-SG may be regarded as a MAP independent index of arterial health and CVD risk in older adults.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T09:43:48.409Z","creation":"2025-04-05T09:43:48.409Z"},"accession":"S-EPMC8570989","cross_references":{"pubmed":["34343145"],"doi":["10.1097/hjh.0000000000002937","10.1097/HJH.0000000000002937"]}}