biostudies-literature00530Unknown20Cui M<b>Objective:</b> To explore the function of the miR-18a-5p/CPEB3 axis in regulating the occurrence of hepatocellular carcinoma (HCC). <b>Methods:</b> Differentially expressed miRNAs and mRNAs were acquired by bioinformatics analysis. qRT-PCR was used for miR-18a-5p and CPEB3 mRNA expression detection. Cell functional assays were implemented to examine the biological functions of HCC cells. The binding relationship between miR-18a-5p and CPEB3 was verified by a dual luciferase assay. <b>Results:</b> In HCC, miR-18a-5p was remarkably highly expressed, while CPEB3 was markedly lowly expressed. HCC cell progression was facilitated after cells transfecting miR-18a-5p mimic, whereas silencing miR-18a-5p caused the opposite result. Overexpressing CPEB3 could restore promoting effect of miR-18a-5p on the growth of HCC cells. <b>Conclusion:</b> Oncogene miR-18a-5p accelerates malignant phenotype by suppressing CPEB3. MiR-18a-5p/CPEB3 axis in HCC identified in this study provides a new target for HCC treatment.Technology in cancer research & treatment15330338211043976https://www.ebi.ac.uk/biostudies/studies/S-EPMC8573499biostudies-literatureMiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3.PMC8573499Liu XCheng DCui MQu FWang L53falseMiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3.<b>Objective:</b> To explore the function of the miR-18a-5p/CPEB3 axis in regulating the occurrence of hepatocellular carcinoma (HCC). <b>Methods:</b> Differentially expressed miRNAs and mRNAs were acquired by bioinformatics analysis. qRT-PCR was used for miR-18a-5p and CPEB3 mRNA expression detection. Cell functional assays were implemented to examine the biological functions of HCC cells. The binding relationship between miR-18a-5p and CPEB3 was verified by a dual luciferase assay. <b>Results:</b> In HCC, miR-18a-5p was remarkably highly expressed, while CPEB3 was markedly lowly expressed. HCC cell progression was facilitated after cells transfecting miR-18a-5p mimic, whereas silencing miR-18a-5p caused the opposite result. Overexpressing CPEB3 could restore promoting effect of miR-18a-5p on the growth of HCC cells. <b>Conclusion:</b> Oncogene miR-18a-5p accelerates malignant phenotype by suppressing CPEB3. MiR-18a-5p/CPEB3 axis in HCC identified in this study provides a new target for HCC treatment.2021-01-01T00:00:00Z2021 Jan-Dec2024-12-04T04:33:11.943Z2022-02-11T12:35:44.746ZS-EPMC85734993473885410.1177/15330338211043976