biostudies-literatureUnknown14(5)Neleman T<h4>Background</h4>Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE).<h4>Methods</h4>We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE).<h4>Results</h4>In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05-2.17Journal of cardiovascular translational research992-1000https://www.ebi.ac.uk/biostudies/studies/S-EPMC8575752biostudies-literatureThe Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score.PMC8575752Tovar Forero MNZijlstra FHartman EMJNeleman TVan Mieghem NMCummins PLiu Svan Soest GDaemen JLigthart JMRWitberg KTBoersma EfalseThe Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score.<h4>Background</h4>Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE).<h4>Methods</h4>We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE).<h4>Results</h4>In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05-2.172021-01-01T00:00:00Z2021 Oct2025-05-29T19:37:51.469Z2025-05-29T19:37:51.469ZS-EPMC85757523362425910.1007/s12265-021-10103-1