biostudies-literatureUnknown13(10)Del Calvo H<h4>Background</h4>Multiple randomized controlled trials have shown that multimodal therapy provides the best overall survival for patients who had locally advanced esophageal cancer. However, it is unknown if multimodal therapy offers the best overall survival in octogenarians.<h4>Methods</h4>We performed retrospective cohort study using data obtained from the National Cancer Database (NCDB) for octogenarians who had locally advanced esophageal cancer from 2004 to 2015. We evaluated the 5-year overall survival for patients among different therapies. We compared the 5-year overall survival between patients receiving chemoradiation therapy followed by surgery and a propensity-matched group of patients who underwent chemoradiation only.<h4>Results</h4>There were 21,710 octogenarians (15%) wiJournal of thoracic disease5875-5886https://www.ebi.ac.uk/biostudies/studies/S-EPMC8575846biostudies-literatureSurgery provides improved overall survival in surgically fit octogenarians with esophageal cancer after chemoradiation therapy.PMC8575846Chan EYKim MPNguyen DTDel Calvo HChihara RGraviss EAfalseSurgery provides improved overall survival in surgically fit octogenarians with esophageal cancer after chemoradiation therapy.<h4>Background</h4>Multiple randomized controlled trials have shown that multimodal therapy provides the best overall survival for patients who had locally advanced esophageal cancer. However, it is unknown if multimodal therapy offers the best overall survival in octogenarians.<h4>Methods</h4>We performed retrospective cohort study using data obtained from the National Cancer Database (NCDB) for octogenarians who had locally advanced esophageal cancer from 2004 to 2015. We evaluated the 5-year overall survival for patients among different therapies. We compared the 5-year overall survival between patients receiving chemoradiation therapy followed by surgery and a propensity-matched group of patients who underwent chemoradiation only.<h4>Results</h4>There were 21,710 octogenarians (15%) wi2021-01-01T00:00:00Z2021 Oct2025-04-04T13:58:11.426Z2025-04-04T13:58:11.426ZS-EPMC85758463479593610.21037/jtd-21-928