{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(10)"],"submitter":["Murrone A"],"pubmed_abstract":["Background
Malignant pleural mesothelioma (MPM) is an aggressive disease, with few available treatment options. Identification of novel prognostic and predictive biomarkers is a priority. In MPM patients, BRCA-associated protein 1 (BAP1) alterations are detected in about 60% of cases and miR-31 seems to be involved in BAP1 regulation at post-transcriptional level. The aim of this study was to evaluate the interaction between BAP1 and miR-31 in MPM and their prognostic role in MPM.Methods
The expression of BAP1 and miR-31 was analyzed in tissues of 55 MPM patients treated with first-line chemotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed by Kaplan-Meier method and Log-rank test was used to investigate differences among subgroups. Multivaria"],"journal":["Journal of thoracic disease"],"pagination":["5741-5751"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8575852"],"repository":["biostudies-literature"],"pubmed_title":["BRCA-associated protein 1 (BAP1) and miR-31 combination predicts outcomes in epithelioid malignant pleural mesothelioma."],"pmcid":["PMC8575852"],"pubmed_authors":["Rinaldi S","Giampieri R","Murrone A","Bianchi F","Tomasetti M","Fiordoliva I","Rubini C","Berardi R","Copparoni C","Monaco F","Cimadamore A","Santarelli L","Cognigni V","Amati M","Pecci F","Cantini L","Barbisan F"],"additional_accession":[]},"is_claimable":false,"name":"BRCA-associated protein 1 (BAP1) and miR-31 combination predicts outcomes in epithelioid malignant pleural mesothelioma.","description":"Background
Malignant pleural mesothelioma (MPM) is an aggressive disease, with few available treatment options. Identification of novel prognostic and predictive biomarkers is a priority. In MPM patients, BRCA-associated protein 1 (BAP1) alterations are detected in about 60% of cases and miR-31 seems to be involved in BAP1 regulation at post-transcriptional level. The aim of this study was to evaluate the interaction between BAP1 and miR-31 in MPM and their prognostic role in MPM.Methods
The expression of BAP1 and miR-31 was analyzed in tissues of 55 MPM patients treated with first-line chemotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed by Kaplan-Meier method and Log-rank test was used to investigate differences among subgroups. Multivaria","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T13:57:42.778Z","creation":"2025-04-04T13:57:42.778Z"},"accession":"S-EPMC8575852","cross_references":{"pubmed":["34795923"],"doi":["10.21037/jtd-21-555"]}}