biostudies-literatureUnknown13(10)Murrone A<h4>Background</h4>Malignant pleural mesothelioma (MPM) is an aggressive disease, with few available treatment options. Identification of novel prognostic and predictive biomarkers is a priority. In MPM patients, BRCA-associated protein 1 (BAP1) alterations are detected in about 60% of cases and miR-31 seems to be involved in BAP1 regulation at post-transcriptional level. The aim of this study was to evaluate the interaction between BAP1 and miR-31 in MPM and their prognostic role in MPM.<h4>Methods</h4>The expression of BAP1 and miR-31 was analyzed in tissues of 55 MPM patients treated with first-line chemotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed by Kaplan-Meier method and Log-rank test was used to investigate differences among subgroups. MultivariaJournal of thoracic disease5741-5751https://www.ebi.ac.uk/biostudies/studies/S-EPMC8575852biostudies-literatureBRCA-associated protein 1 (BAP1) and miR-31 combination predicts outcomes in epithelioid malignant pleural mesothelioma.PMC8575852Rinaldi SGiampieri RMurrone ABianchi FTomasetti MFiordoliva IRubini CBerardi RCopparoni CMonaco FCimadamore ASantarelli LCognigni VAmati MPecci FCantini LBarbisan FfalseBRCA-associated protein 1 (BAP1) and miR-31 combination predicts outcomes in epithelioid malignant pleural mesothelioma.<h4>Background</h4>Malignant pleural mesothelioma (MPM) is an aggressive disease, with few available treatment options. Identification of novel prognostic and predictive biomarkers is a priority. In MPM patients, BRCA-associated protein 1 (BAP1) alterations are detected in about 60% of cases and miR-31 seems to be involved in BAP1 regulation at post-transcriptional level. The aim of this study was to evaluate the interaction between BAP1 and miR-31 in MPM and their prognostic role in MPM.<h4>Methods</h4>The expression of BAP1 and miR-31 was analyzed in tissues of 55 MPM patients treated with first-line chemotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed by Kaplan-Meier method and Log-rank test was used to investigate differences among subgroups. Multivaria2021-01-01T00:00:00Z2021 Oct2025-04-04T13:57:42.778Z2025-04-04T13:57:42.778ZS-EPMC85758523479592310.21037/jtd-21-555