biostudies-literatureUnknown125(10)Aliagas E<h4>Background</h4>There is no effective therapy for patients with malignant pleural mesothelioma (MPM) who progressed to platinum-based chemotherapy and immunotherapy.<h4>Methods</h4>We aimed to investigate the antitumor activity of CDK4/6 inhibitors using in vitro and in vivo preclinical models of MPM.<h4>Results</h4>Based on publicly available transcriptomic data of MPM, patients with CDK4 or CDK6 overexpression had shorter overall survival. Treatment with abemaciclib or palbociclib at 100 nM significantly decreased cell proliferation in all cell models evaluated. Both CDK4/6 inhibitors significantly induced G1 cell cycle arrest, thereby increasing cell senescence and increased the expression of interferon signalling pathway and tumour antigen presentation process in culture models of MBritish journal of cancer1365-1376https://www.ebi.ac.uk/biostudies/studies/S-EPMC8576019biostudies-literatureEfficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma.PMC8576019Llatjos RHernandez-Madrigal MVarela MRuffinelli JCVidal ASanchez-Cespedes MSharkley AJPros EAliagas EPalmero RAso SNadal EPadrones SDawson AEscobar ISole XVillanueva AMunoz-Pinedo CSaigi MDorca ERamos RAlay ABusacca SCordero DMartinez-Iniesta MFennell DGausachs MfalseEfficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma.<h4>Background</h4>There is no effective therapy for patients with malignant pleural mesothelioma (MPM) who progressed to platinum-based chemotherapy and immunotherapy.<h4>Methods</h4>We aimed to investigate the antitumor activity of CDK4/6 inhibitors using in vitro and in vivo preclinical models of MPM.<h4>Results</h4>Based on publicly available transcriptomic data of MPM, patients with CDK4 or CDK6 overexpression had shorter overall survival. Treatment with abemaciclib or palbociclib at 100 nM significantly decreased cell proliferation in all cell models evaluated. Both CDK4/6 inhibitors significantly induced G1 cell cycle arrest, thereby increasing cell senescence and increased the expression of interferon signalling pathway and tumour antigen presentation process in culture models of M2021-01-01T00:00:00Z2021 Nov2026-05-08T11:20:28.054Z2025-04-19T11:44:19.528ZS-EPMC85760193458861510.1038/s41416-021-01547-y