{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nimkulrat SD"],"funding":["NIDDK NIH HHS","NCRR NIH HHS"],"pagination":["2058-2066"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8576426"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(9)"],"pubmed_abstract":["Loss of mature β-cell function and identity, or β-cell dedifferentiation, is seen in both type 1 and type 2 diabetes. Two competing models explain β-cell dedifferentiation in diabetes. In the first model, β-cells dedifferentiate in the reverse order of their developmental ontogeny. This model predicts that dedifferentiated β-cells resemble β-cell progenitors. In the second model, β-cell dedifferentiation depends on the type of diabetogenic stress. This model, which we call the \"Anna Karenina\" model, predicts that in each type of diabetes, β-cells dedifferentiate in their own way, depending on how their mature identity is disrupted by any particular diabetogenic stress. We directly tested the two models using a β-cell-specific lineage-tracing system coupled with RNA sequencing in mice. We c"],"journal":["Diabetes"],"pubmed_title":["The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes."],"pmcid":["PMC8576426"],"funding_grant_id":["S10 RR025483","R56 DK115837"],"pubmed_authors":["Nimkulrat SD","Ni Z","Bernstein MN","Brown J","Kendziorski C","Blum B"],"additional_accession":[]},"is_claimable":false,"name":"The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes.","description":"Loss of mature β-cell function and identity, or β-cell dedifferentiation, is seen in both type 1 and type 2 diabetes. Two competing models explain β-cell dedifferentiation in diabetes. In the first model, β-cells dedifferentiate in the reverse order of their developmental ontogeny. This model predicts that dedifferentiated β-cells resemble β-cell progenitors. In the second model, β-cell dedifferentiation depends on the type of diabetogenic stress. This model, which we call the \"Anna Karenina\" model, predicts that in each type of diabetes, β-cells dedifferentiate in their own way, depending on how their mature identity is disrupted by any particular diabetogenic stress. We directly tested the two models using a β-cell-specific lineage-tracing system coupled with RNA sequencing in mice. We c","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-18T18:43:02.071Z","creation":"2025-04-07T06:24:26.405Z"},"accession":"S-EPMC8576426","cross_references":{"pubmed":["34417264"],"doi":["10.2337/db21-0211"]}}