{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Docherty KF"],"funding":["British Heart Foundation","NIDDK NIH HHS"],"pagination":["1298-1305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8576587"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(11)"],"pubmed_abstract":["<h4>Importance</h4>Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure and reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits of sodium glucose cotransporter 2 inhibitors a helpful addition to clinical trial results when communicating the benefits of this class of drug to patients.<h4>Objective</h4>To estimate the projected long-term treatment effects of dapagliflozin in patients with HFrEF over the duration of a patient's lifetime.<h4>Design, setting, and participants</h4>Exploratory analysis was performed of Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF), a phase 3 randomized, placebo-controlled clinical trial conducted at 410 sites in 20 countries. Patients "],"journal":["JAMA cardiology"],"pubmed_title":["Extrapolating Long-term Event-Free and Overall Survival With Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis of a Phase 3 Randomized Clinical Trial."],"pmcid":["PMC8576587"],"funding_grant_id":["P30 DK045735","RE/18/6/34217"],"pubmed_authors":["Ince C","Mahapekar M","Saito K","Poirier P","Karageorgiev D","Mohri M","Vyselaar J","Fairman E","Seki K","Kitakaze M","Hiroi S","Kosiborod MN","Antalik L","Rupka D","Langkilde AM","Van Eck J","Japp A","Nunohiro T","Uchida I","Teel J","Moritani K","Akinboboye O","Hashimoto T","Jarai Z","Albisu J","Takase H","Kopylov P","Malek I","Hickey G","Slovenska M","Aizenberg D","Tschope D","Katova T","Masszi G","Kuramochi T","Fulop P","Majercak I","Spasova N","Takeyasu N","Mahal S","Dong W","Dong Y","Foley B","Pawlowicz L","Nguyen Vinh P","O'Meara E","Haddad T","Kolomanov B","Dong J","Garcia Brasca D","Lieber I","Anzai T","Younis L","Arif A","Kothiwale V","Martinez D","Botushanov N","Genth-Zotz S","Franchi F","Liu J","Aksentiev S","Liu M","Liu P","Vizel S","Nischik R","Zoet Nugteren S","Tomasova L","Ezhov A","Pesant Y","Weiss S","Pandey A","Nagashima H","Vasconcellos E","Sala J","Al-Zoebi A","Robles De Medina R","Bennett M","Harada K","Sassone S","Tereshchenko S","Syed F","Mooe T","MirekBryniarska E","Onishi Y","Venugopal C","Guo X","Liang Y","Schou M","Costard-Jackle A","Hajek P","Shah K","Pham V","Mckelvie R","Jhund P","Kucera D","Inzucchi SE","Fujimoto N","Nani S","Momiyama Y","Howlett J","Luquez H","Lo E","Fujimoto K","Nishino M","Desai A","Solomon SD","Kimura A","Claggett B","Poor F","Bernstein M","Kiyosue A","Singal D","Vishneva E","Sjostrand M","Kazemi N","Bengtsson O","Manenti E","Perna E","Kuwahara K","Belohlavek J","Paolino B","Korzeniak R","Selecky J","Nilk R","Chang H","Macek V","Chang K","DeMets DL","Kiraly C","Komiyama N","Berk M","Izzo J","Han B","Peng D","Londono J","Docherty KF","Fu L","Sudnik W","Paraschos A","Mercau G","Leaes P","Lampart J","Greene T","Petrie M","Fujii K","Paltsman Z","Udgire P","Ge J","Vladeva S","Ivanova Y","Schmidt E","Chopra V","Sumii K","Lang C","Saraiva J","Van Hessen M","Mody F","Pimentel P","Petrie C","Okumura Y","Smik R","Yao L","Mariankowski R","Komura Y","Noori E","Bugan V","Fukui K","Busak L","Sabatine MS","Hirohata A","Ponikowski P","Najenson M","Tokmakova M","Jardula M","Fong P","Takahashi W","Prokopczuk J","DAPA-HF Investigators and Committees","Bellersen L","Takahashi N","Levinson L","Spinarova L","Constance C","Gu Y","Witek R","Hotchkiss D","Schabauer A","Hove J","Sosa Liprandi A","Ogunniyi M","Matsuoka S","Mayer O","Krcova E","Gogov A","Arakawa T","Lin T","Florea V","Lin X","Kawamura R","Reis G","Colombo Berra F","Stephan U","Rossi P","Videbæk L","Maia L","Kokane H","Asakura M","Raev D","Nikfarjam A","Caruso G","Patel J","Avramov D","Inoue S","McMurray JJV","Kollarova D","Runev N","Miekus P","Mihov A","Galyavich A","Nicolau JC","Hershson A","Do H","Zaidman C","Wilke A","Sandhu M","Nasser-Sharif F","Shilko J","Lin L","Jaffrani N","Cha J","Nierop P","Merkely B","Meno H","Nagy L","Hernandes M","Zhao Q","De Boer R","Cimato T","Pereira A","Talavera M","Higashiue S","Vinanska D","Weigmann I","Sugino H","Hamroff G","Maung TZ","Chiang CE","Vijayaraghavan R","Lederman S","Azzari F","Bertolet B","Takagi Y","Swart H","Ljungman C","Hedman A","Dukat A","Gupta D","Cluigt N","Ueno H","Mehta S","Manshadi R","Mehta V","Castriz J","Phaneuf D","Chompalova B","Kostis J","Milanova M","Lewis T","Li X","Hominal M","Li Y","Li Z","Wada A","Jhund PS","De Nooijer C","Ramanathan K","Dzhaiani N","Lewis G","Dincheva A","Rassi S","Suzuki S","Hayashi Y","Ferreira JP","Pevzner D","Suzuki M","Chandra L","Jiang H","Hisamatsu Y","Iliev N","Czigany A","Yasaka Y","Wakefield P","Ahuad Guerrero R","Pursley M","Precoma D","Emani S","Verma S","Kasai T","Sciborski R","Khaykin Y","Lindholm C","Walsh J","Ueda Y","Toursarkissian N","Shih J","Zhang X","Kanwar M","Neuenschwander F","Drelich G","Clark A","Truong B","Tereschenko S","Leslie S","Jamriskova L","Pereiro Gonzalez S","Shinozaki T","Szynal S","Dalcoquio T","Iskander S","Kuchar R","Zheng Z","Menon J","Uchikawa S","Maltcev A","Carda J","Skopek J","Murphy C","Zacharias M","Fruehling E","Tsukahara K","Bohm M","Efremov I","Bhargava V","Andrassy P","Lee R","Martinez FA","Katayama Y","Iseki H","Javier J","Garcia Duran R","Miklaszewicz B","Chernyavsky A","Egstrup K","Arouni A","Tanaka S","Gardner R","Tang Q","Chiang C","Cheng R","Spinar J","Montana O","Tomobuchi Y","Hsieh I","Sotolongo R","Arantes F","Boldueva S","Nassif M","Lash J","Chehayeb R","Zhou Y","Fernandez A","Motyovszki A","Huang W","Gadkari M","Deshpande M","Koziolova N","Ilieva K","Appel K","Drozdz J","Kazakov A","Wu L","Hsia C","Al-Joundi B","Sinha D","Huang J","Kober L","Wang D","Wu C","Guimaraes F","Brown C","Karna S","Avino D","Hata Y","Lindmark K","Deleon S","Simonis G","Babapulle M","Wang Z","Tsutsui H","Anand I","Ho D","Ermoshkina L","Kostenko V","Krylova L","Shibasaki T","Kellerer M","Kakuta T","Naik A","Sinha S","Taborda J","Slaby J","Kadokami T","Mansour S","Diez M","Noguchi Y","Joseph S","Viera A","Gislason G","Tseng W","French W","Hartleib M","Banerjee S","Majul C","Higuchi M","Staniloae C","Cursack G","Nguyen T","Song D","Sawant R","Srivastava S","Groenemeijer B","Nguyen H","Didenko Y","Hattori E","Kamiya H","Kantaros L","Borges J","Olexa P"],"additional_accession":[]},"is_claimable":false,"name":"Extrapolating Long-term Event-Free and Overall Survival With Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis of a Phase 3 Randomized Clinical Trial.","description":"<h4>Importance</h4>Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure and reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits of sodium glucose cotransporter 2 inhibitors a helpful addition to clinical trial results when communicating the benefits of this class of drug to patients.<h4>Objective</h4>To estimate the projected long-term treatment effects of dapagliflozin in patients with HFrEF over the duration of a patient's lifetime.<h4>Design, setting, and participants</h4>Exploratory analysis was performed of Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF), a phase 3 randomized, placebo-controlled clinical trial conducted at 410 sites in 20 countries. Patients ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-09T03:57:12.091Z","creation":"2022-08-06T22:43:45.29Z"},"accession":"S-EPMC8576587","cross_references":{"pubmed":["34319398"],"doi":["10.1001/jamacardio.2021.2632"]}}