{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(20)"],"submitter":["Li YX"],"pubmed_abstract":["<h4>Background</h4>The precise pathogenesis of ankylosing spondylitis (AS) is still largely unknown at present. Our previous study found that toll-like receptor 4 (TLR4) downregulated and performed immunoregulatory dysfunction in mesenchymal stem cells from AS patients (AS-MSCs). The aim of this study was to explore the expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in TLR4-primed AS-MSCs, and to clarify the potential mechanisms.<h4>Methods</h4>The immunoregulatory effects of MSCs were determined after TLR4 activation. Next, the differentially-expressed (DE) lncRNAs and mRNAs between AS-MSCs and TLR4-primed AS-MSCs [stimulated by lipopolysaccharide (LPS)] were identified via high-throughput sequencing followed by quantitative real-time PCR (qRT-PCR) confir"],"journal":["Annals of translational medicine"],"pagination":["1563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8576702"],"repository":["biostudies-literature"],"pubmed_title":["Integrative analysis of long non-coding RNA and messenger RNA expression in toll-like receptor 4-primed mesenchymal stem cells of ankylosing spondylitis."],"pmcid":["PMC8576702"],"pubmed_authors":["Huang JJ","Lu SX","Liang YW","Liu XG","Cheng ZY","Huang L","Liu T","Li YX","Huang JS","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Integrative analysis of long non-coding RNA and messenger RNA expression in toll-like receptor 4-primed mesenchymal stem cells of ankylosing spondylitis.","description":"<h4>Background</h4>The precise pathogenesis of ankylosing spondylitis (AS) is still largely unknown at present. Our previous study found that toll-like receptor 4 (TLR4) downregulated and performed immunoregulatory dysfunction in mesenchymal stem cells from AS patients (AS-MSCs). The aim of this study was to explore the expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in TLR4-primed AS-MSCs, and to clarify the potential mechanisms.<h4>Methods</h4>The immunoregulatory effects of MSCs were determined after TLR4 activation. Next, the differentially-expressed (DE) lncRNAs and mRNAs between AS-MSCs and TLR4-primed AS-MSCs [stimulated by lipopolysaccharide (LPS)] were identified via high-throughput sequencing followed by quantitative real-time PCR (qRT-PCR) confir","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T02:25:40.353Z","creation":"2022-02-11T13:00:37.634Z"},"accession":"S-EPMC8576702","cross_references":{"pubmed":["34790769"],"doi":["10.21037/atm-21-5020"]}}