{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(20)"],"submitter":["Gorenjak V"],"pubmed_abstract":["Telomere length (TL) is a hallmark of cellular aging and is associated with chronic diseases development. The vascular endothelial growth factor A (VEGF-A), a potent angiogenesis factor, is implicated in the pathophysiology of many chronic diseases. The aim of the present study was to investigate the associations between VEGF-A and TL. TL in leukocytes (LTL) and skeletal muscle (MTL) were measured, 10 VEGF-related polymorphisms genotyped, and VEGF-A plasma concentrations determined in 402 individuals from the TELARTA cohort. LTL/MTL ratio was calculated as an estimate of lifelong TL attrition. Associations between VEGF-A variants and levels, and TL parameters were investigated. We identified one significant association between the minor allele (T) of rs6993770 variant and LTL/MTL ratio (P="],"journal":["Aging"],"pagination":["23517-23526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8580333"],"repository":["biostudies-literature"],"pubmed_title":["A genetic determinant of VEGF-A levels is associated with telomere attrition."],"pmcid":["PMC8580333"],"pubmed_authors":["Lamont J","Benetos A","Gorenjak V","Masson C","Kumar S","Labat C","Stathopoulou MG","Toupance S","TELARTA Consortium","Murray H","Visvikis-Siest S","Fitzgerald P","Petrelis AM"],"additional_accession":[]},"is_claimable":false,"name":"A genetic determinant of VEGF-A levels is associated with telomere attrition.","description":"Telomere length (TL) is a hallmark of cellular aging and is associated with chronic diseases development. The vascular endothelial growth factor A (VEGF-A), a potent angiogenesis factor, is implicated in the pathophysiology of many chronic diseases. The aim of the present study was to investigate the associations between VEGF-A and TL. TL in leukocytes (LTL) and skeletal muscle (MTL) were measured, 10 VEGF-related polymorphisms genotyped, and VEGF-A plasma concentrations determined in 402 individuals from the TELARTA cohort. LTL/MTL ratio was calculated as an estimate of lifelong TL attrition. Associations between VEGF-A variants and levels, and TL parameters were investigated. We identified one significant association between the minor allele (T) of rs6993770 variant and LTL/MTL ratio (P=","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-06-01T12:24:57.619Z","creation":"2022-02-11T14:14:14.124Z"},"accession":"S-EPMC8580333","cross_references":{"pubmed":["34661551"],"doi":["10.18632/aging.203636"]}}