{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Canedo T"],"funding":["Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation)","Fundação Bial (Bial Foundation)"],"pagination":["2358-2370"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8581027"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(13)"],"pubmed_abstract":["Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders triggered by neuroinflammation. In this study, we investigated the mechanisms underlying the aberrant activation of microglia elicited by Meth in the adult mouse brain. We found that binge Meth exposure caused microgliosis and disrupted risk assessment behavior (a feature that usually occurs in individuals who abuse Meth), both of which required astrocyte-to-microglia crosstalk. Mechani"],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine."],"pmcid":["PMC8581027"],"funding_grant_id":["art. 23 of Law no. 57/2016","SFRH/BD/147981/2019","037/18","PD/BD/135450/2017","UIDB/50026/2020","PTDC/SAU-TOX/30647/2017","2020.07188.BD","207/14","PTDC/MED-NEU/31417/2017","IF/00753/2014","SFRH/BD/117148/2016","SFRH/BD/144324/2019"],"pubmed_authors":["Sousa N","Silva AI","Relvas JB","Bravo J","Socodato R","Canedo T","Almeida TO","Terceiro AF","Magalhaes A","Summavielle T","Portugal CC","Magalhaes JD","Guerra-Gomes S","Oliveira JF"],"additional_accession":[]},"is_claimable":false,"name":"Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine.","description":"Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders triggered by neuroinflammation. In this study, we investigated the mechanisms underlying the aberrant activation of microglia elicited by Meth in the adult mouse brain. We found that binge Meth exposure caused microgliosis and disrupted risk assessment behavior (a feature that usually occurs in individuals who abuse Meth), both of which required astrocyte-to-microglia crosstalk. Mechani","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T10:17:42.029Z","creation":"2025-04-05T10:17:42.029Z"},"accession":"S-EPMC8581027","cross_references":{"pubmed":["34400780"],"doi":["10.1038/s41386-021-01139-7"]}}