{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Day JD"],"funding":["NIBIB NIH HHS","AHRQ HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["754127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8582279"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["COVID-19 presentations range from mild to moderate through severe disease but also manifest with persistent illness or viral recrudescence. We hypothesized that the spectrum of COVID-19 disease manifestations was a consequence of SARS-CoV-2-mediated delay in the pathogen-associated molecular pattern (PAMP) response, including dampened type I interferon signaling, thereby shifting the balance of the immune response to be dominated by damage-associated molecular pattern (DAMP) signaling. To test the hypothesis, we constructed a parsimonious mechanistic mathematical model. After calibration of the model for initial viral load and then by varying a few key parameters, we show that the core model generates four distinct viral load, immune response and associated disease trajectories termed \"pat"],"journal":["Frontiers in immunology"],"pubmed_title":["Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model."],"pmcid":["PMC8582279"],"funding_grant_id":["R21 NS113055","T32 HS026121","U01 EB021960"],"pubmed_authors":["Singh H","Ranard BL","Vodovotz Y","Day JD","Park S","Chow CC"],"additional_accession":[]},"is_claimable":false,"name":"Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model.","description":"COVID-19 presentations range from mild to moderate through severe disease but also manifest with persistent illness or viral recrudescence. We hypothesized that the spectrum of COVID-19 disease manifestations was a consequence of SARS-CoV-2-mediated delay in the pathogen-associated molecular pattern (PAMP) response, including dampened type I interferon signaling, thereby shifting the balance of the immune response to be dominated by damage-associated molecular pattern (DAMP) signaling. To test the hypothesis, we constructed a parsimonious mechanistic mathematical model. After calibration of the model for initial viral load and then by varying a few key parameters, we show that the core model generates four distinct viral load, immune response and associated disease trajectories termed \"pat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T10:51:49.152Z","creation":"2022-02-11T12:50:30.718Z"},"accession":"S-EPMC8582279","cross_references":{"pubmed":["34777366"],"doi":["10.3389/fimmu.2021.754127"]}}