biostudies-literatureChailangkarn TThailand Science Research and Innovation (TSRI)11986https://www.ebi.ac.uk/biostudies/studies/S-EPMC8584829biostudies-literatureUnknown22(21)Rabies is a deadly viral disease caused by the rabies virus (RABV), transmitted through a bite of an infected host, resulting in irreversible neurological symptoms and a 100% fatality rate in humans. Despite many aspects describing rabies neuropathogenesis, numerous hypotheses remain unanswered and concealed. Observations obtained from infected primary neurons or mouse brain samples are more relevant to human clinical rabies than permissive cell lines; however, limitations regarding the ethical issue and sample accessibility become a hurdle for discovering new insights into virus-host interplays. To better understand RABV pathogenesis in humans, we generated human-induced pluripotent stem cell (hiPSC)-derived neurons to offer the opportunity for an inimitable study of RABV infection at a mInternational journal of molecular sciencesEstablishment of Human-Induced Pluripotent Stem Cell-Derived Neurons-A Promising In Vitro Model for a Molecular Study of Rabies Virus and Host Interaction.PMC85848296280011Tangphatsornruang SLekcharoensuk PKaewborisuth CTanwattana NWanasen NJantraphakorn YLeetanasaksakul KChankeeree PLumlertdacha BChailangkarn TNawae WSriswasdi SJaemthaworn TfalseEstablishment of Human-Induced Pluripotent Stem Cell-Derived Neurons-A Promising In Vitro Model for a Molecular Study of Rabies Virus and Host Interaction.Rabies is a deadly viral disease caused by the rabies virus (RABV), transmitted through a bite of an infected host, resulting in irreversible neurological symptoms and a 100% fatality rate in humans. Despite many aspects describing rabies neuropathogenesis, numerous hypotheses remain unanswered and concealed. Observations obtained from infected primary neurons or mouse brain samples are more relevant to human clinical rabies than permissive cell lines; however, limitations regarding the ethical issue and sample accessibility become a hurdle for discovering new insights into virus-host interplays. To better understand RABV pathogenesis in humans, we generated human-induced pluripotent stem cell (hiPSC)-derived neurons to offer the opportunity for an inimitable study of RABV infection at a m2021-01-01T00:00:00Z2021 Nov2026-04-08T07:11:46.493Z2022-02-11T14:58:12.159ZS-EPMC85848293476941610.3390/ijms222111986