{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brown LK"],"funding":["NICHD NIH HHS","NIAID NIH HHS"],"pagination":["497-505"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8585710"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(5)"],"pubmed_abstract":["<h4>Background</h4>Depression is frequent among youth living with HIV (YLWH). Studies suggest that manualized treatment guided by symptom measurement is more efficacious than usual care.<h4>Setting</h4>This study evaluated manualized, measurement-guided depression treatment among YLWH, aged 12-24 years at 13 US sites of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network.<h4>Methods</h4>Using restricted randomization, sites were assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB-R) tailored for YLWH or to enhanced standard of care, which provided standard psychotherapy and medication management. Eligibility included diagnosis of nonpsychotic depression and current depressive symptoms. Arm comparisons use"],"journal":["Journal of acquired immune deficiency syndromes (1999)"],"pubmed_title":["Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States."],"pmcid":["PMC8585710"],"funding_grant_id":["UM1 AI068632","UM1 AI106716","P30 AI042853","HHSN275201800001I","HHSN275201800001C","UM1 AI068616"],"pubmed_authors":["Townley E","Chernoff M","IMPAACT 2002 team","Kennard BD","Emslie GJ","Traite S","Buisson S","Harriff L","Agwu A","Whiteley LB","Spector SA","Weinberg A","Shapiro DE","Brown LK","Shaw R","Krotje C","Lypen K","Bunch A","Purswani M"],"additional_accession":[]},"is_claimable":false,"name":"Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States.","description":"<h4>Background</h4>Depression is frequent among youth living with HIV (YLWH). Studies suggest that manualized treatment guided by symptom measurement is more efficacious than usual care.<h4>Setting</h4>This study evaluated manualized, measurement-guided depression treatment among YLWH, aged 12-24 years at 13 US sites of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network.<h4>Methods</h4>Using restricted randomization, sites were assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB-R) tailored for YLWH or to enhanced standard of care, which provided standard psychotherapy and medication management. Eligibility included diagnosis of nonpsychotic depression and current depressive symptoms. Arm comparisons use","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-26T10:00:11.466Z","creation":"2024-12-04T00:23:36.764Z"},"accession":"S-EPMC8585710","cross_references":{"pubmed":["34483297"],"doi":["10.1097/QAI.0000000000002790","10.1097/qai.0000000000002790"]}}