biostudies-literatureBrown LKNICHD NIH HHSNIAID NIH HHS497-505https://www.ebi.ac.uk/biostudies/studies/S-EPMC8585710biostudies-literatureUnknown88(5)<h4>Background</h4>Depression is frequent among youth living with HIV (YLWH). Studies suggest that manualized treatment guided by symptom measurement is more efficacious than usual care.<h4>Setting</h4>This study evaluated manualized, measurement-guided depression treatment among YLWH, aged 12-24 years at 13 US sites of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network.<h4>Methods</h4>Using restricted randomization, sites were assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB-R) tailored for YLWH or to enhanced standard of care, which provided standard psychotherapy and medication management. Eligibility included diagnosis of nonpsychotic depression and current depressive symptoms. Arm comparisons useJournal of acquired immune deficiency syndromes (1999)Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States.PMC8585710UM1 AI068632UM1 AI106716P30 AI042853HHSN275201800001IHHSN275201800001CUM1 AI068616Townley EChernoff MIMPAACT 2002 teamKennard BDEmslie GJTraite SBuisson SHarriff LAgwu AWhiteley LBSpector SAWeinberg AShapiro DEBrown LKShaw RKrotje CLypen KBunch APurswani MfalseSite-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States.<h4>Background</h4>Depression is frequent among youth living with HIV (YLWH). Studies suggest that manualized treatment guided by symptom measurement is more efficacious than usual care.<h4>Setting</h4>This study evaluated manualized, measurement-guided depression treatment among YLWH, aged 12-24 years at 13 US sites of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network.<h4>Methods</h4>Using restricted randomization, sites were assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB-R) tailored for YLWH or to enhanced standard of care, which provided standard psychotherapy and medication management. Eligibility included diagnosis of nonpsychotic depression and current depressive symptoms. Arm comparisons use2021-01-01T00:00:00Z2021 Dec2025-04-26T10:00:11.466Z2024-12-04T00:23:36.764ZS-EPMC85857103448329710.1097/QAI.000000000000279010.1097/qai.0000000000002790