biostudies-literatureUnknown21(1)Nguyen QDCIHR<h4>Background</h4>Not all research findings are translated to clinical practice. Reasons for lack of applicability are varied, and multiple frameworks and criteria exist to appraise the general applicability of epidemiological and clinical research. In this two-part study, we identify, map, and synthesize frameworks and criteria; we develop a framework to assist clinicians to appraise applicability specifically from a clinical perspective.<h4>Methods</h4>We conducted a literature search in PubMed and Embase to identify frameworks appraising applicability of study results. Conceptual thematic analysis was used to synthesize frameworks and criteria. We carried out a framework development process integrating contemporary debates in epidemiology, findings from the literature search and syntheBMC medical research methodology248https://www.ebi.ac.uk/biostudies/studies/S-EPMC8590785biostudies-literatureAppraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist.PMC8590785Saeed SGoulden RKeezer MRMoodie EMNguyen QDPeters EForget MFDesmarais PWolfson CfalseAppraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist.<h4>Background</h4>Not all research findings are translated to clinical practice. Reasons for lack of applicability are varied, and multiple frameworks and criteria exist to appraise the general applicability of epidemiological and clinical research. In this two-part study, we identify, map, and synthesize frameworks and criteria; we develop a framework to assist clinicians to appraise applicability specifically from a clinical perspective.<h4>Methods</h4>We conducted a literature search in PubMed and Embase to identify frameworks appraising applicability of study results. Conceptual thematic analysis was used to synthesize frameworks and criteria. We carried out a framework development process integrating contemporary debates in epidemiology, findings from the literature search and synthe2021-01-01T00:00:00Z2021 Nov2025-04-04T10:21:41.76Z2022-02-11T12:55:30.852ZS-EPMC85907853477399410.1186/s12874-021-01445-0