{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsiao JJ"],"funding":["University of Iowa Start up funds","U.S. Department of Defense"],"pagination":["22208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8592995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Supraphysiologic androgen (SPA) inhibits cell proliferation in prostate cancer (PCa) cells by transcriptional repression of DNA replication and cell-cycle genes. In this study, quantitative glycoprotein profiling identified androgen-regulated glycoprotein networks associated with SPA-mediated inhibition of PCa cell proliferation, and androgen-regulated glycoproteins in clinical prostate tissues. SPA-regulated glycoprotein networks were enriched for translation factors and ribosomal proteins, proteins that are known to be O-GlcNAcylated in response to various cellular stresses. Thus, androgen-regulated glycoproteins are likely to be targeted for O-GlcNAcylation. Comparative analysis of glycosylated proteins in PCa cells and clinical prostate tissue identified androgen-regulated glycoprotein"],"journal":["Scientific reports"],"pubmed_title":["Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases."],"pmcid":["PMC8592995"],"funding_grant_id":["W81XWH-08-1-0471"],"pubmed_authors":["Hsiao JJ","Wright ME","Ng BH","Lee J","Smits MM"],"additional_accession":[]},"is_claimable":false,"name":"Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases.","description":"Supraphysiologic androgen (SPA) inhibits cell proliferation in prostate cancer (PCa) cells by transcriptional repression of DNA replication and cell-cycle genes. In this study, quantitative glycoprotein profiling identified androgen-regulated glycoprotein networks associated with SPA-mediated inhibition of PCa cell proliferation, and androgen-regulated glycoproteins in clinical prostate tissues. SPA-regulated glycoprotein networks were enriched for translation factors and ribosomal proteins, proteins that are known to be O-GlcNAcylated in response to various cellular stresses. Thus, androgen-regulated glycoproteins are likely to be targeted for O-GlcNAcylation. Comparative analysis of glycosylated proteins in PCa cells and clinical prostate tissue identified androgen-regulated glycoprotein","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T03:24:48.885Z","creation":"2025-05-29T20:26:09.328Z"},"accession":"S-EPMC8592995","cross_references":{"pubmed":["34782677"],"doi":["10.1038/s41598-021-01554-2"]}}