{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["175"],"submitter":["Villa A"],"funding":["Fondazione Cariplo","University of Milan","Scuola Superiore Sant'Anna","Istituto Italiano di Tecnologia"],"pubmed_abstract":["All the different coronavirus SARS-CoV-2 variants isolated so far share the same mechanism of infection mediated by the interaction of their spike (S) glycoprotein with specific residues on their cellular receptor: the angiotensin converting enzyme 2 (ACE2). Therefore, the steric hindrance on this cellular receptor created by a bulk macromolecule may represent an effective strategy for the prevention of the viral spreading and the onset of severe forms of Corona Virus disease 19 (COVID-19). Here, we applied a systematic evolution of ligands by exponential enrichment (SELEX) procedure to identify two single strand DNA molecules (aptamers) binding specifically to the region surrounding the K353, the key residue in human ACE2 interacting with the N501 amino acid of the SARS-CoV-2 S. 3D dockin"],"journal":["Pharmacological research"],"pagination":["105982"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8594078"],"repository":["biostudies-literature"],"pubmed_title":["DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic."],"pmcid":["PMC8594078"],"pubmed_authors":["Villa A","Rebecchi M","De Francesco R","Ciana P","Lionetti V","Donnici L","Brunialti E","Meda C","Conti M","Dellavedova J","Reggiani A"],"additional_accession":[]},"is_claimable":false,"name":"DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.","description":"All the different coronavirus SARS-CoV-2 variants isolated so far share the same mechanism of infection mediated by the interaction of their spike (S) glycoprotein with specific residues on their cellular receptor: the angiotensin converting enzyme 2 (ACE2). Therefore, the steric hindrance on this cellular receptor created by a bulk macromolecule may represent an effective strategy for the prevention of the viral spreading and the onset of severe forms of Corona Virus disease 19 (COVID-19). Here, we applied a systematic evolution of ligands by exponential enrichment (SELEX) procedure to identify two single strand DNA molecules (aptamers) binding specifically to the region surrounding the K353, the key residue in human ACE2 interacting with the N501 amino acid of the SARS-CoV-2 S. 3D dockin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-08T06:57:54.21Z","creation":"2024-11-07T01:27:59.269Z"},"accession":"S-EPMC8594078","cross_references":{"pubmed":["34798263"],"doi":["10.1016/j.phrs.2021.105982"]}}