{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai BQ"],"funding":["Science and Technology Commission Foundation of Si Chuan Province"],"pagination":["9355555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8595022"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["Increasing evidence indicates that nuclear factor, erythroid 2-like 3 (Nrf3) is connected with tumorigenesis. However, the relationship between Nrf3 and tumor drug resistance remains elusive. In this study, we investigated the effect and mechanism of action by which Nrf3 regulated the sensitivity of colon cancer cells to 5-fluorouracil (5-FU). We found Nrf3 was significantly increased in colon cancer tissues. Furthermore, we observed that Nrf3 knockdown and overexpression can significantly affect the sensitivity of colon cancer cells to 5-FU in vitro and in vivo. Moreover, Nrf3 promoted the expression of RELA, P-RELA, and BCL-2. Inhibition of NF-<i>κ</i>B partly reversed the effects of Nrf3 overexpression, resulting in the resistance of colon cancer cells to 5-FU. Overall, the study reveal"],"journal":["Journal of oncology"],"pubmed_title":["Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-<i>κ</i>B/BCL-2 Signaling Pathway In Vitro and In Vivo."],"pmcid":["PMC8595022"],"funding_grant_id":["18SXHZ0213","19SXHZ0324","20SXCXTD004","2018JY0478"],"pubmed_authors":["Chen WM","Zhao J","Tang JC","Cai BQ","Hou W"],"additional_accession":[]},"is_claimable":false,"name":"Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-<i>κ</i>B/BCL-2 Signaling Pathway In Vitro and In Vivo.","description":"Increasing evidence indicates that nuclear factor, erythroid 2-like 3 (Nrf3) is connected with tumorigenesis. However, the relationship between Nrf3 and tumor drug resistance remains elusive. In this study, we investigated the effect and mechanism of action by which Nrf3 regulated the sensitivity of colon cancer cells to 5-fluorouracil (5-FU). We found Nrf3 was significantly increased in colon cancer tissues. Furthermore, we observed that Nrf3 knockdown and overexpression can significantly affect the sensitivity of colon cancer cells to 5-FU in vitro and in vivo. Moreover, Nrf3 promoted the expression of RELA, P-RELA, and BCL-2. Inhibition of NF-<i>κ</i>B partly reversed the effects of Nrf3 overexpression, resulting in the resistance of colon cancer cells to 5-FU. Overall, the study reveal","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-29T19:22:17.411Z","creation":"2025-05-29T19:22:17.411Z"},"accession":"S-EPMC8595022","cross_references":{"pubmed":["34795760"],"doi":["10.1155/2021/9355555"]}}