{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Penuelas-Urquides K"],"funding":["Consejo Nacional de Ciencia y Tecnología","Junta de Castilla y León","Ministerio de Economía y Competitividad"],"pubmed_abstract":["The emergence of multidrug-resistant (MDR) <i>Mycobacterium tuberculosis</i> strains threaten the control of tuberculosis. New antitubercular dihydrosphingosine analogs, named UCIs, have been evaluated in preclinical studies but their cellular and molecular mechanisms of action against <i>M. tuberculosis</i> are still unknown. The aim of this study was to evaluate the effect of UCI exposure on gene expression of drug-sensitive H37Rv and MDR CIBIN:UMF:15:99 clones of <i>M. tuberculosis</i> which were isolated, phenotypically, and genetically characterized, cultured to log phase and treated with UCI compounds; followed by total RNA isolation, reverse transcription and hybridization assays on Affymetrix genomic microarrays. Data were validated with RT-qPCR assays. As results, UCI-05 and UCI-1"],"journal":["Frontiers in microbiology"],"pagination":["742867"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8595602"],"repository":["biostudies-literature"],"pubmed_title":["Two New Dihydrosphingosine Analogs Against <i>Mycobacterium tuberculosis</i> Affect <i>gltA1</i>, <i>lprQ, and rpsO</i> Expression."],"pmcid":["PMC8595602"],"pubmed_authors":["Villarreal-Trevino L","Del Olmo E","Becerril-Montes P","Molina-Salinas GM","Penuelas-Urquides K","Gonzalez-Escalante LA","Bermudez de Leon M","Castorena-Torres F","San Feliciano A","Castro-Garza J","Silva-Ramirez B","Said-Fernandez S"],"additional_accession":[]},"is_claimable":false,"name":"Two New Dihydrosphingosine Analogs Against <i>Mycobacterium tuberculosis</i> Affect <i>gltA1</i>, <i>lprQ, and rpsO</i> Expression.","description":"The emergence of multidrug-resistant (MDR) <i>Mycobacterium tuberculosis</i> strains threaten the control of tuberculosis. New antitubercular dihydrosphingosine analogs, named UCIs, have been evaluated in preclinical studies but their cellular and molecular mechanisms of action against <i>M. tuberculosis</i> are still unknown. The aim of this study was to evaluate the effect of UCI exposure on gene expression of drug-sensitive H37Rv and MDR CIBIN:UMF:15:99 clones of <i>M. tuberculosis</i> which were isolated, phenotypically, and genetically characterized, cultured to log phase and treated with UCI compounds; followed by total RNA isolation, reverse transcription and hybridization assays on Affymetrix genomic microarrays. Data were validated with RT-qPCR assays. As results, UCI-05 and UCI-1","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T01:01:44.529Z","creation":"2022-02-11T13:20:29.553Z"},"accession":"S-EPMC8595602","cross_references":{"pubmed":["34803964"],"doi":["10.3389/fmicb.2021.742867"]}}