{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marchlewicz E"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NIEHS NIH HHS","EPA","NCI NIH HHS","NIH"],"pagination":["131645"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8595757"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["286(Pt 2)"],"pubmed_abstract":["The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol A (BPA) on the developmental trajectory of NAFLD in offspring, we exposed dams from pre-gestation through lactation to a human-relevant dose of oral BPA coupled with intake of high fat Western or Mediterranean-style diets. We assessed hepatic steatosis by quantifying hepatic triglycerides (TGs) and metabolic health by measuring body weight, relative organ weights, and serum hormone levels in dams and offspring at postnatal day 10 (PND10) and 10-months of age. In dams, consumption of the Western "],"journal":["Chemosphere"],"pubmed_title":["Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams."],"pmcid":["PMC8595757"],"funding_grant_id":["P30 ES017885","P30 DK089503","P30 DK020572","P30 CA046592","T32 ES007062","R35 ES031686","P01 ES022844","T32 HD079342","F31 ES025101"],"pubmed_authors":["Peterson K","Hoenerhoff M","Tang L","Djuric Z","Marchlewicz E","McCabe C","Padmanabhan V","Dolinoy DC","Barks J","Song PX"],"additional_accession":[]},"is_claimable":false,"name":"Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.","description":"The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol A (BPA) on the developmental trajectory of NAFLD in offspring, we exposed dams from pre-gestation through lactation to a human-relevant dose of oral BPA coupled with intake of high fat Western or Mediterranean-style diets. We assessed hepatic steatosis by quantifying hepatic triglycerides (TGs) and metabolic health by measuring body weight, relative organ weights, and serum hormone levels in dams and offspring at postnatal day 10 (PND10) and 10-months of age. In dams, consumption of the Western ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-26T13:22:39.2Z","creation":"2025-04-06T14:15:11.89Z"},"accession":"S-EPMC8595757","cross_references":{"pubmed":["34426127"],"doi":["10.1016/j.chemosphere.2021.131645"]}}