{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["73(11)"],"submitter":["Styrkarsdottir U"],"pubmed_abstract":["<h4>Objective</h4>Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.<h4>Methods</h4>Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case-control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.<h4>Results</h4>Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95%"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pagination":["2025-2034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8596997"],"repository":["biostudies-literature"],"pubmed_title":["The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland."],"pmcid":["PMC8596997"],"pubmed_authors":["Saevarsdottir S","Bjornsdottir G","Gudbjartsson D","Norddahl GL","Stefansson K","Lund SH","Jonsson H","Magnusson MI","Ivarsdottir EV","Sulem P","Frigge ML","Gunnarsdottir K","Styrkarsdottir U","Thorgeirsson G","Jonsdottir I","Ingvarsson T","Holm H","Rafnar T","Thorsteinsdottir U"],"additional_accession":[]},"is_claimable":false,"name":"The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland.","description":"<h4>Objective</h4>Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.<h4>Methods</h4>Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case-control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.<h4>Results</h4>Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95%","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-26T17:54:51.257Z","creation":"2022-02-11T13:05:32.673Z"},"accession":"S-EPMC8596997","cross_references":{"pubmed":["33982893"],"doi":["10.1002/art.41793"]}}