biostudies-literatureUnknown73(11)Styrkarsdottir U<h4>Objective</h4>Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.<h4>Methods</h4>Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case-control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.<h4>Results</h4>Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95%Arthritis & rheumatology (Hoboken, N.J.)2025-2034https://www.ebi.ac.uk/biostudies/studies/S-EPMC8596997biostudies-literatureThe CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland.PMC8596997Saevarsdottir SBjornsdottir GGudbjartsson DNorddahl GLStefansson KLund SHJonsson HMagnusson MIIvarsdottir EVSulem PFrigge MLGunnarsdottir KStyrkarsdottir UThorgeirsson GJonsdottir IIngvarsson THolm HRafnar TThorsteinsdottir UfalseThe CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland.<h4>Objective</h4>Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.<h4>Methods</h4>Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case-control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.<h4>Results</h4>Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95%2021-01-01T00:00:00Z2021 Nov2025-04-26T17:54:51.257Z2022-02-11T13:05:32.673ZS-EPMC85969973398289310.1002/art.41793