{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deng L"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["1968-1976"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8597419"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["Bergenin, which is isolated from <i>Bergenia</i> species, exhibits various pharmacological properties. In the search for new types of immunosuppressants, a series of bergenin derivatives were designed and synthesized, and their immunosuppressive effects were evaluated by the CCK-8 assay. The experimental data demonstrated that compounds <b>7</b> and <b>13</b> showed the strongest inhibition effects on mouse splenocyte proliferation (IC<sub>50</sub> = 3.52 and 5.39 μM, respectively). Further studies revealed that the inhibitory effect may come from the suppression of both IFN-γ and IL-4 cytokines. Alkylated derivatives of bergenin with <i>n</i>-hexyl and <i>n</i>-heptyl on the two phenolic hydroxyl groups showed better inhibitory activities. The hydrophobicity of bergenin derivatives, the c"],"journal":["RSC medicinal chemistry"],"pubmed_title":["Synthesis and biological evaluation of bergenin derivatives as new immunosuppressants."],"pmcid":["PMC8597419"],"funding_grant_id":["2018YFA0507602","91853122","21977004","81821004"],"pubmed_authors":["Wang M","Wu YF","Song C","Deng L","Li Q","Ye XS","Niu Y"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and biological evaluation of bergenin derivatives as new immunosuppressants.","description":"Bergenin, which is isolated from <i>Bergenia</i> species, exhibits various pharmacological properties. In the search for new types of immunosuppressants, a series of bergenin derivatives were designed and synthesized, and their immunosuppressive effects were evaluated by the CCK-8 assay. The experimental data demonstrated that compounds <b>7</b> and <b>13</b> showed the strongest inhibition effects on mouse splenocyte proliferation (IC<sub>50</sub> = 3.52 and 5.39 μM, respectively). Further studies revealed that the inhibitory effect may come from the suppression of both IFN-γ and IL-4 cytokines. Alkylated derivatives of bergenin with <i>n</i>-hexyl and <i>n</i>-heptyl on the two phenolic hydroxyl groups showed better inhibitory activities. The hydrophobicity of bergenin derivatives, the c","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-22T09:59:44.853Z","creation":"2025-04-05T23:24:08.777Z"},"accession":"S-EPMC8597419","cross_references":{"pubmed":["34825192"],"doi":["10.1039/d1md00210d"]}}