biostudies-literatureCox GWGouvernement du Canada | Canadian Institutes of Health Research (CIHR)Gouvernement du Canada | Canadian Institutes of Health Researche0096621https://www.ebi.ac.uk/biostudies/studies/S-EPMC8597779biostudies-literatureUnknown65(12)We investigated whether the increased prevalence of gentamicin resistance in Salmonella from human infections was related to a similar increased prevalence in isolates from broiler chickens and whether this increase may have been due to coselection from use of lincomycin-spectinomycin in chickens on farms. Whole-genome sequencing was performed on gentamicin-resistant (Gen^r) Salmonella isolates from human and chicken sources collected from 2014 to 2017 by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). We determined the genomic relatedness of strains and characterized resistance genes and plasmids. From 2014 to 2017, 247 isolates of Gen^r Salmonella were identified by CIPARS: 188 were from humans, and 59 were from chicken sources (26 Antimicrobial agents and chemotherapyA One-Health Genomic Investigation of Gentamicin Resistance in Salmonella from Human and Chicken Sources in Canada, 2014 to 2017.PMC8597779CFC-150770Deckert AEBekal SAllen VChui LIrwin RJCox GWEl Bailey SBharat ADaignault DZahariadis GHaldane DHoang LReid-Smith RJParmley EJAlexander DCAvery BPFinley RLMinion JGerman GJMulvey MRfalseA One-Health Genomic Investigation of Gentamicin Resistance in Salmonella from Human and Chicken Sources in Canada, 2014 to 2017.We investigated whether the increased prevalence of gentamicin resistance in Salmonella from human infections was related to a similar increased prevalence in isolates from broiler chickens and whether this increase may have been due to coselection from use of lincomycin-spectinomycin in chickens on farms. Whole-genome sequencing was performed on gentamicin-resistant (Gen^r) Salmonella isolates from human and chicken sources collected from 2014 to 2017 by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). We determined the genomic relatedness of strains and characterized resistance genes and plasmids. From 2014 to 2017, 247 isolates of Gen^r Salmonella were identified by CIPARS: 188 were from humans, and 59 were from chicken sources (26 2021-01-01T00:00:00Z2021 Nov2026-06-15T03:09:45.579Z2024-11-15T20:18:42.528ZS-EPMC85977793457064210.1128/AAC.00966-2110.1128/aac.00966-21