{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Montravers P"],"funding":["Direction de la Recherche Clinique de l’Assistance Publique des Hôpitaux de Paris","Programme Hospitalier de Recherche Clinique","French Ministry of Health"],"pagination":["3303-3309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8598293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(12)"],"pubmed_abstract":["<h4>Background</h4>Therapeutic failure is a frequent issue in the management of post-operative peritonitis.<h4>Objectives</h4>A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.<h4>Patients and methods</h4>Overall failures assessed post-operatively between Day 8 and Day 45 were defined as a composite of death and/or surgical and/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.<h4>Results</h4>Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological fa"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Risk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial."],"pmcid":["PMC8598293"],"funding_grant_id":["AOM 09024"],"pubmed_authors":["Beaussier M","Eloy P","Grall N","Besch G","Levrard M","Lescot T","Desmard M","Gaillard T","Blasco G","Montravers P","Herault MC","Launey Y","Plantefeve G","Georger JF","DURAPOP trial group","Auboyer C","Paugam C","Floch T","Dupont H","Pease S","Jaber S","Gally J","Perrier JF","Gergaud S","Clavier T","Raclot P","Cinotti R","Tesniere A","Pily-Floury S","Veber B","Seguin P","Samain E","Belhadj-Tahar N","Mignon A","Pajot O","Wallet F","Esposito-Farese M","Weiss E","Abback P","Tassin C","Cousson J","Mahjoub Y","Payen JF","Delay JM","Gouin P","Asehnoune K","Jung B","Girard C","Bronchard R","Collanges O","Lepape A","Meistelman C","Piriou V","Lasocki S"],"additional_accession":[]},"is_claimable":false,"name":"Risk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial.","description":"<h4>Background</h4>Therapeutic failure is a frequent issue in the management of post-operative peritonitis.<h4>Objectives</h4>A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.<h4>Patients and methods</h4>Overall failures assessed post-operatively between Day 8 and Day 45 were defined as a composite of death and/or surgical and/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.<h4>Results</h4>Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological fa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-07-14T13:22:23.57Z","creation":"2022-02-11T13:01:29.203Z"},"accession":"S-EPMC8598293","cross_references":{"pubmed":["34458922"],"doi":["10.1093/jac/dkab307"]}}