biostudies-literatureMontravers PDirection de la Recherche Clinique de l’Assistance Publique des Hôpitaux de ParisProgramme Hospitalier de Recherche CliniqueFrench Ministry of Health3303-3309https://www.ebi.ac.uk/biostudies/studies/S-EPMC8598293biostudies-literatureUnknown76(12)<h4>Background</h4>Therapeutic failure is a frequent issue in the management of post-operative peritonitis.<h4>Objectives</h4>A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.<h4>Patients and methods</h4>Overall failures assessed post-operatively between Day 8 and Day 45 were defined as a composite of death and/or surgical and/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.<h4>Results</h4>Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological faThe Journal of antimicrobial chemotherapyRisk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial.PMC8598293AOM 09024Beaussier MEloy PGrall NBesch GLevrard MLescot TDesmard MGaillard TBlasco GMontravers PHerault MCLauney YPlantefeve GGeorger JFDURAPOP trial groupAuboyer CPaugam CFloch TDupont HPease SJaber SGally JPerrier JFGergaud SClavier TRaclot PCinotti RTesniere APily-Floury SVeber BSeguin PSamain EBelhadj-Tahar NMignon APajot OWallet FEsposito-Farese MWeiss EAbback PTassin CCousson JMahjoub YPayen JFDelay JMGouin PAsehnoune KJung BGirard CBronchard RCollanges OLepape AMeistelman CPiriou VLasocki SfalseRisk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial.<h4>Background</h4>Therapeutic failure is a frequent issue in the management of post-operative peritonitis.<h4>Objectives</h4>A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.<h4>Patients and methods</h4>Overall failures assessed post-operatively between Day 8 and Day 45 were defined as a composite of death and/or surgical and/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.<h4>Results</h4>Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological fa2021-01-01T00:00:00Z2021 Nov2026-07-14T13:22:23.57Z2022-02-11T13:01:29.203ZS-EPMC85982933445892210.1093/jac/dkab307