{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Ahmed H"],"pubmed_abstract":["Recently, alternative therapies are gaining popularity in the treatment of epilepsy. The present study aimed to find out the antiepileptic potential of quercetin, catechin, and kaempferol. <i>In vivo</i> and <i>in silico</i> experiments were conducted to investigate their therapeutic potential. 25 mg/kg/day of pentylenetetrazole was administered for 4 weeks after epilepsy was induced in the rats; this was followed by the behavioral studies and histological analysis of rat brain slices. Binding affinities of kaempferol, quercetin, and catechin were assessed by performing <i>in silico</i> studies. Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV). The mRNA levels of SV2A,"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["754952"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8599161"],"repository":["biostudies-literature"],"pubmed_title":["<i>In Silico</i> and <i>In Vivo</i>: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model."],"pmcid":["PMC8599161"],"pubmed_authors":["Ahmed H","Ali Zaidi SA","Muhammad S","Khan MA"],"additional_accession":[]},"is_claimable":false,"name":"<i>In Silico</i> and <i>In Vivo</i>: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model.","description":"Recently, alternative therapies are gaining popularity in the treatment of epilepsy. The present study aimed to find out the antiepileptic potential of quercetin, catechin, and kaempferol. <i>In vivo</i> and <i>in silico</i> experiments were conducted to investigate their therapeutic potential. 25 mg/kg/day of pentylenetetrazole was administered for 4 weeks after epilepsy was induced in the rats; this was followed by the behavioral studies and histological analysis of rat brain slices. Binding affinities of kaempferol, quercetin, and catechin were assessed by performing <i>in silico</i> studies. Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV). The mRNA levels of SV2A,","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-27T21:57:12.237Z","creation":"2022-02-11T13:23:30.445Z"},"accession":"S-EPMC8599161","cross_references":{"pubmed":["34805114"],"doi":["10.3389/fbioe.2021.754952"]}}