biostudies-literatureUnknown9Ahmed HRecently, alternative therapies are gaining popularity in the treatment of epilepsy. The present study aimed to find out the antiepileptic potential of quercetin, catechin, and kaempferol. <i>In vivo</i> and <i>in silico</i> experiments were conducted to investigate their therapeutic potential. 25 mg/kg/day of pentylenetetrazole was administered for 4 weeks after epilepsy was induced in the rats; this was followed by the behavioral studies and histological analysis of rat brain slices. Binding affinities of kaempferol, quercetin, and catechin were assessed by performing <i>in silico</i> studies. Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV). The mRNA levels of SV2A,Frontiers in bioengineering and biotechnology754952https://www.ebi.ac.uk/biostudies/studies/S-EPMC8599161biostudies-literature<i>In Silico</i> and <i>In Vivo</i>: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model.PMC8599161Ahmed HAli Zaidi SAMuhammad SKhan MAfalse<i>In Silico</i> and <i>In Vivo</i>: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model.Recently, alternative therapies are gaining popularity in the treatment of epilepsy. The present study aimed to find out the antiepileptic potential of quercetin, catechin, and kaempferol. <i>In vivo</i> and <i>in silico</i> experiments were conducted to investigate their therapeutic potential. 25 mg/kg/day of pentylenetetrazole was administered for 4 weeks after epilepsy was induced in the rats; this was followed by the behavioral studies and histological analysis of rat brain slices. Binding affinities of kaempferol, quercetin, and catechin were assessed by performing <i>in silico</i> studies. Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV). The mRNA levels of SV2A,2021-01-01T00:00:00Z20212026-05-27T21:57:12.237Z2022-02-11T13:23:30.445ZS-EPMC85991613480511410.3389/fbioe.2021.754952