{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Asrani K"],"funding":["NCI NIH HHS","National Institutes of Health"],"pagination":["425-437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8599638"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["255(4)"],"pubmed_abstract":["Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1). Here, using diverse cancer gene expression datasets, we show that Hippo pathway-related genes, including YAP1, are among the top down-regulated gene sets with expression of the neuroendocrine transcripti"],"journal":["The Journal of pathology"],"pubmed_title":["Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer."],"pmcid":["PMC8599638"],"funding_grant_id":["P30 CA006973","P50CA58236","R01 CA234715","P50 CA058236","P01 CA163227","P50CA087186","P50 CA097186"],"pubmed_authors":["De Marzo AM","Hanratty B","Asrani K","Coleman I","Vidotto T","Yegnasubramanian S","Lotan TL","Tsai HK","Torres AF","Luo J","Haffner MC","Nelson PS","Corey E","Woo J"],"additional_accession":[]},"is_claimable":false,"name":"Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer.","description":"Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1). Here, using diverse cancer gene expression datasets, we show that Hippo pathway-related genes, including YAP1, are among the top down-regulated gene sets with expression of the neuroendocrine transcripti","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-06-04T03:00:53.27Z","creation":"2025-04-04T19:38:01.384Z"},"accession":"S-EPMC8599638","cross_references":{"pubmed":["34431104"],"doi":["10.1002/path.5781"]}}