biostudies-literatureAsrani KNCI NIH HHSNational Institutes of Health425-437https://www.ebi.ac.uk/biostudies/studies/S-EPMC8599638biostudies-literatureUnknown255(4)Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1). Here, using diverse cancer gene expression datasets, we show that Hippo pathway-related genes, including YAP1, are among the top down-regulated gene sets with expression of the neuroendocrine transcriptiThe Journal of pathologyReciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer.PMC8599638P30 CA006973P50CA58236R01 CA234715P50 CA058236P01 CA163227P50CA087186P50 CA097186De Marzo AMHanratty BAsrani KColeman IVidotto TYegnasubramanian SLotan TLTsai HKTorres AFLuo JHaffner MCNelson PSCorey EWoo JfalseReciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer.Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC-adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1). Here, using diverse cancer gene expression datasets, we show that Hippo pathway-related genes, including YAP1, are among the top down-regulated gene sets with expression of the neuroendocrine transcripti2021-01-01T00:00:00Z2021 Dec2026-06-04T03:00:53.27Z2025-04-04T19:38:01.384ZS-EPMC85996383443110410.1002/path.5781