{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye XL"],"funding":["Natural Science Foundation of China","China Mega-project for Infectious Diseases","Peking University Medicine Fund of Fostering Young Scholars’ Scientific &amp; Technological Innovation"],"pagination":["133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8600349"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.<h4>Methods</h4>A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.<h4>Results</h4>Totally 886 individuals we"],"journal":["Infectious diseases of poverty"],"pubmed_title":["Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China."],"pmcid":["PMC8600349"],"funding_grant_id":["2018ZX10713002","2018ZX10301401","82073617","81825019"],"pubmed_authors":["Li H","Li JC","Cui N","Liu K","Fang LQ","Yang ZD","Zhang XA","Zhang JS","Lu QB","Liu W","Zhang HY","Yuan C","Yang Y","Lv SM","Zhang PH","Huang YQ","Ye XL","Dai K"],"additional_accession":[]},"is_claimable":false,"name":"Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China.","description":"<h4>Background</h4>Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.<h4>Methods</h4>A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.<h4>Results</h4>Totally 886 individuals we","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-18T13:27:22.702Z","creation":"2022-02-11T13:03:32.8Z"},"accession":"S-EPMC8600349","cross_references":{"pubmed":["34794512"],"doi":["10.1186/s40249-021-00918-0"]}}