biostudies-literatureYe XLNatural Science Foundation of ChinaChina Mega-project for Infectious DiseasesPeking University Medicine Fund of Fostering Young Scholars’ Scientific &amp; Technological Innovation133https://www.ebi.ac.uk/biostudies/studies/S-EPMC8600349biostudies-literatureUnknown10(1)<h4>Background</h4>Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.<h4>Methods</h4>A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.<h4>Results</h4>Totally 886 individuals weInfectious diseases of povertyInfection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China.PMC86003492018ZX107130022018ZX103014018207361781825019Li HLi JCCui NLiu KFang LQYang ZDZhang XAZhang JSLu QBLiu WZhang HYYuan CYang YLv SMZhang PHHuang YQYe XLDai KfalseInfection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China.<h4>Background</h4>Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.<h4>Methods</h4>A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.<h4>Results</h4>Totally 886 individuals we2021-01-01T00:00:00Z2021 Nov2025-04-18T13:27:22.702Z2022-02-11T13:03:32.8ZS-EPMC86003493479451210.1186/s40249-021-00918-0