{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu YJ"],"funding":["Key Technologies Research and Development Program","National Major Science and Technology Projects of China","National Natural Science Foundation of China","Guangdong Key Laboratory of Innovation Method and Decision Management System"],"pagination":["610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8600893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
The accumulation of single nucleotide variants (SNVs) and the emergence of neoantigens can affect tumour proliferation and the immune microenvironment. However, the SNV-related immune microenvironment characteristics and key genes involved in hepatocellular carcinoma (HCC) are still unclear. We aimed to evaluate differences in the SNV-related immune microenvironment, construct a prognostic model and validate the key genes in vitro.Methods
The categories of samples were defined by the expression of SNV score-related genes to evaluate the differences in mutational features, immune environment and prognosis. The survival model was constructed with survival-associated genes and verified in two independent test datasets. RCAN2, the key gene screened out for biofunctio"],"journal":["Cancer cell international"],"pubmed_title":["Construction of a single nucleotide variant score-related gene-based prognostic model in hepatocellular carcinoma: analysis of multi-independent databases and validation in vitro."],"pmcid":["PMC8600893"],"funding_grant_id":["2019B110233002","No. 81625017","2017YFA0505803","No. 82072610","2018ZX10302205"],"pubmed_authors":["Shi M","He MK","Kan A","Xu YJ","Bu XY","Liu S","Huang LC"],"additional_accession":[]},"is_claimable":false,"name":"Construction of a single nucleotide variant score-related gene-based prognostic model in hepatocellular carcinoma: analysis of multi-independent databases and validation in vitro.","description":"Background
The accumulation of single nucleotide variants (SNVs) and the emergence of neoantigens can affect tumour proliferation and the immune microenvironment. However, the SNV-related immune microenvironment characteristics and key genes involved in hepatocellular carcinoma (HCC) are still unclear. We aimed to evaluate differences in the SNV-related immune microenvironment, construct a prognostic model and validate the key genes in vitro.Methods
The categories of samples were defined by the expression of SNV score-related genes to evaluate the differences in mutational features, immune environment and prognosis. The survival model was constructed with survival-associated genes and verified in two independent test datasets. RCAN2, the key gene screened out for biofunctio","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T12:07:18.938Z","creation":"2022-02-11T13:03:45.208Z"},"accession":"S-EPMC8600893","cross_references":{"pubmed":["34794449"],"doi":["10.1186/s12935-021-02321-z"]}}