{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vinh DN"],"funding":["Wellcome Trust"],"pagination":["6680"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8602397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The relationship between age and seroprevalence can be used to estimate the annual attack rate of an infectious disease. For pathogens with multiple serologically distinct strains, there is a need to describe composite exposure to an antigenically variable group of pathogens. In this study, we assay 24,402 general-population serum samples, collected in Vietnam between 2009 to 2015, for antibodies to eleven human influenza A strains. We report that a principal components decomposition of antibody titer data gives the first principal component as an appropriate surrogate for seroprevalence; this results in annual attack rate estimates of 25.6% (95% CI: 24.1% - 27.1%) for subtype H3 and 16.0% (95% CI: 14.7% - 17.3%) for subtype H1. The remaining principal components separate the strains by se"],"journal":["Nature communications"],"pubmed_title":["Age-seroprevalence curves for the multi-strain structure of influenza A virus."],"pmcid":["PMC8602397"],"funding_grant_id":["089276","098511/Z/12/Z","089276/B/09/7","097465/B/11/Z"],"pubmed_authors":["Quan TM","Thwaites GE","Nguyen TD","Vy NHT","Thanh NTL","Clapham HE","de Bruin E","Thao TTN","Todd S","Choisy M","Thai PQ","Lien NTN","Boni MF","Hong TTK","Anh PH","Nhat NTD","Ha NTH","Simmons CP","Chau NVV","Phuong HT","Koopmans M","Vinh DN"],"additional_accession":[]},"is_claimable":false,"name":"Age-seroprevalence curves for the multi-strain structure of influenza A virus.","description":"The relationship between age and seroprevalence can be used to estimate the annual attack rate of an infectious disease. For pathogens with multiple serologically distinct strains, there is a need to describe composite exposure to an antigenically variable group of pathogens. In this study, we assay 24,402 general-population serum samples, collected in Vietnam between 2009 to 2015, for antibodies to eleven human influenza A strains. We report that a principal components decomposition of antibody titer data gives the first principal component as an appropriate surrogate for seroprevalence; this results in annual attack rate estimates of 25.6% (95% CI: 24.1% - 27.1%) for subtype H3 and 16.0% (95% CI: 14.7% - 17.3%) for subtype H1. The remaining principal components separate the strains by se","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-07-16T13:58:44.991Z","creation":"2022-02-11T13:26:29.986Z"},"accession":"S-EPMC8602397","cross_references":{"pubmed":["34795239"],"doi":["10.1038/s41467-021-26948-8"]}}