biostudies-literatureUnknown22(1)Wang T<h4>Background</h4>Sanghuangporus sanghuang is a well-known traditional medicinal mushroom associated with mulberry. Despite the properties of this mushroom being known for many years, the regulatory mechanisms of bioactive compound biosynthesis in this medicinal mushroom are still unclear. Lysine malonylation is a posttranslational modification that has many critical functions in various aspects of cell metabolism. However, at present we do not know its role in S. sanghuang. In this study, a global investigation of the lysine malonylome in S. sanghuang was therefore carried out.<h4>Results</h4>In total, 714 malonyl modification sites were matched to 255 different proteins. The analysis indicated that malonyl modifications were involved in a wide range of cellular functions and displayed aBMC genomics840https://www.ebi.ac.uk/biostudies/studies/S-EPMC8603570biostudies-literatureSystematic analysis of the lysine malonylome in Sanghuangporus sanghuang.PMC8603570Zhang GZhou LTian XWang TWang GHou RfalseSystematic analysis of the lysine malonylome in Sanghuangporus sanghuang.<h4>Background</h4>Sanghuangporus sanghuang is a well-known traditional medicinal mushroom associated with mulberry. Despite the properties of this mushroom being known for many years, the regulatory mechanisms of bioactive compound biosynthesis in this medicinal mushroom are still unclear. Lysine malonylation is a posttranslational modification that has many critical functions in various aspects of cell metabolism. However, at present we do not know its role in S. sanghuang. In this study, a global investigation of the lysine malonylome in S. sanghuang was therefore carried out.<h4>Results</h4>In total, 714 malonyl modification sites were matched to 255 different proteins. The analysis indicated that malonyl modifications were involved in a wide range of cellular functions and displayed a2021-01-01T00:00:00Z2021 Nov2025-04-19T05:03:46.863Z2022-02-11T13:01:38.412ZS-EPMC86035703479881310.1186/s12864-021-08120-0