biostudies-literatureUnknown22(1)Arabi YM<h4>Background</h4>It is unclear whether screening for sepsis using an electronic alert in hospitalized ward patients improves outcomes. The objective of the Stepped-wedge Cluster Randomized Trial of Electronic Early Notification of Sepsis in Hospitalized Ward Patients (SCREEN) trial is to evaluate whether an electronic screening for sepsis compared to no screening among hospitalized ward patients reduces all-cause 90-day in-hospital mortality.<h4>Methods and design</h4>This study is designed as a stepped-wedge cluster randomized trial in which the unit of randomization or cluster is the hospital ward. An electronic alert for sepsis was developed in the electronic medical record (EMR), with the feature of being active (visible to treating team) or masked (inactive in EMR frontend for the tTrials828https://www.ebi.ac.uk/biostudies/studies/S-EPMC8607063biostudies-literatureStatistical analysis plan for the Steppedwedge Cluster Randomized trial of Electronic Early Notification of sepsis in hospitalized ward patients (SCREEN).PMC8607063Abdukahil SASCREEN Trial GroupAl Shammari HAlmughamisi NAl Qarni AAl Tabsh HAlMarhabi HVishwakarma RKRahim AANasser WQureshi ASAl Khathaami AMArabi YMShahin MAlmulhim MAl Qarni MAl Arfaj AMarcelo ALMadram GCaswell AJastaniah WMustafa HTAlyami AHYamani AOAlhabshi MMMunshi AAAbuelgasim KAAl Almoodi RNammour GAlansari MAlshamrani MMAl-Qahtani SGhamdi AAYaakob JQahtani SAlselaim NJones JAlKatheri MEJaber IJAl-Dorzi HMAl Qasim EObbed SAl Qasem AAliyyen SMAlhasani AMAl Zahrani MAl Ghamdi HBanat BRAbuskout OAl Ghamdi EAlwasaidi TAl Moammary MSAl Somali HChalabi JGreyvenstein JEAlWafi EAlchin JAl Shouabi AAlHazme RHAl-Hameed FSian CMAlatassi AAl Mutrafy AAl Anazi REMasala CAl Hamdan AAlyousef ZEsilan HOmaish NSalih SBRasheed SAl-Rabeah FKTalaqof FJazieh ARAlharbi AMatroud AAlsaawi AAbdrabo MTashkandi NQasim SAbdrahim AfalseStatistical analysis plan for the Steppedwedge Cluster Randomized trial of Electronic Early Notification of sepsis in hospitalized ward patients (SCREEN).<h4>Background</h4>It is unclear whether screening for sepsis using an electronic alert in hospitalized ward patients improves outcomes. The objective of the Stepped-wedge Cluster Randomized Trial of Electronic Early Notification of Sepsis in Hospitalized Ward Patients (SCREEN) trial is to evaluate whether an electronic screening for sepsis compared to no screening among hospitalized ward patients reduces all-cause 90-day in-hospital mortality.<h4>Methods and design</h4>This study is designed as a stepped-wedge cluster randomized trial in which the unit of randomization or cluster is the hospital ward. An electronic alert for sepsis was developed in the electronic medical record (EMR), with the feature of being active (visible to treating team) or masked (inactive in EMR frontend for the t2021-01-01T00:00:00Z2021 Nov2026-05-08T18:19:09.602Z2022-02-11T13:11:06.057ZS-EPMC86070633480967210.1186/s13063-021-05788-3