{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sen'kova AV"],"funding":["Russian State funded budget projects of ICBFM","Russian Science Foundation"],"pagination":["e0260450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8608348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["Acute lung injury (ALI) is a specific form of lung damage caused by different infectious and non-infectious agents, including SARS-CoV-2, leading to severe respiratory and systemic inflammation. To gain deeper insight into the molecular mechanisms behind ALI and to identify core elements of the regulatory network associated with this pathology, key genes involved in the regulation of the acute lung inflammatory response (Il6, Ccl2, Cat, Serpine1, Eln, Timp1, Ptx3, Socs3) were revealed using comprehensive bioinformatics analysis of whole-genome microarray datasets, functional annotation of differentially expressed genes (DEGs), reconstruction of protein-protein interaction networks and text mining. The bioinformatics data were validated using a murine model of LPS-induced ALI; changes in th"],"journal":["PloS one"],"pubmed_title":["Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study."],"pmcid":["PMC8608348"],"funding_grant_id":["19-74-30011","0245-2021-0004"],"pubmed_authors":["Zenkova MA","Markov AV","Savin IA","Brenner EV","Sen'kova AV"],"additional_accession":[]},"is_claimable":false,"name":"Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study.","description":"Acute lung injury (ALI) is a specific form of lung damage caused by different infectious and non-infectious agents, including SARS-CoV-2, leading to severe respiratory and systemic inflammation. To gain deeper insight into the molecular mechanisms behind ALI and to identify core elements of the regulatory network associated with this pathology, key genes involved in the regulation of the acute lung inflammatory response (Il6, Ccl2, Cat, Serpine1, Eln, Timp1, Ptx3, Socs3) were revealed using comprehensive bioinformatics analysis of whole-genome microarray datasets, functional annotation of differentially expressed genes (DEGs), reconstruction of protein-protein interaction networks and text mining. The bioinformatics data were validated using a murine model of LPS-induced ALI; changes in th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T20:25:51.153Z","creation":"2022-02-11T13:13:05.301Z"},"accession":"S-EPMC8608348","cross_references":{"pubmed":["34807957"],"doi":["10.1371/journal.pone.0260450"]}}