biostudies-literatureMattern LNIEHS NIH HHSNINDS NIH HHS3953-3960https://www.ebi.ac.uk/biostudies/studies/S-EPMC8608709biostudies-literatureUnknown52(12)<h4>Background and purpose</h4>Despite zinc's role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. To examine the association between serum zinc levels and incidence of ischemic stroke in a US population.<h4>Methods</h4>Using a case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke cohort, participants were randomly selected from the Reasons for Geographic and Racial Differences in Stroke cohort to generate a sub-cohort (n=2346). All incident ischemic stroke cases as of September 2012 (n=660) were included, with 62 incident cases overlapping in the sub-cohort. Serum zinc levels were measured at baseline. Barlow-weighted Cox's proportional hazards regression models were used to StrokeSerum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study.PMC8608709U01 NS041588R01 ES021735Cushman MMcClure LABrockman JMattern LJudd SChen CKahe KfalseSerum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study.<h4>Background and purpose</h4>Despite zinc's role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. To examine the association between serum zinc levels and incidence of ischemic stroke in a US population.<h4>Methods</h4>Using a case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke cohort, participants were randomly selected from the Reasons for Geographic and Racial Differences in Stroke cohort to generate a sub-cohort (n=2346). All incident ischemic stroke cases as of September 2012 (n=660) were included, with 62 incident cases overlapping in the sub-cohort. Serum zinc levels were measured at baseline. Barlow-weighted Cox's proportional hazards regression models were used to 2021-01-01T00:00:00Z2021 Dec2025-04-04T19:37:59.947Z2025-04-04T19:37:59.947ZS-EPMC86087093441251310.1161/STROKEAHA.120.03318710.1161/strokeaha.120.033187