biostudies-literatureYang JNational Natural Science Foundation of ChinaNational Key Research and Development Program of China2881-2891https://www.ebi.ac.uk/biostudies/studies/S-EPMC8608948biostudies-literatureUnknown38(11)<h4>Purpose</h4>To study the application of next-generation sequencing on preimplantation genetic testing for recurrent hydatidiform mole patients.<h4>Methods</h4>A total of ten recurrent hydatidiform mole patients aged 27-34 years with a history of at least twice hydatidiform moles and no normal pregnancy were collected from 2019 to 2020. The diagnosis of hydatidiform mole type was clarified using short tandem repeat genotyping on products of conception, and whole-exome sequencing was applied for all patients and their partners. Seven recurrent hydatidiform mole patients with complete hydatidiform mole/partial hydatidiform mole type among previous hydatidiform mole tissues and no Pathogenetic/Likely pathogenetic/Uncertain significance variants in NLRP7/KHDC3L/MEI1/C11orf80 underwent a proJournal of assisted reproduction and geneticsApplication of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients.PMC860894881971440816714582018YFC1002302Liu YYan LYang JYan ZZhi XLiu PZhu XLi RQiao JfalseApplication of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients.<h4>Purpose</h4>To study the application of next-generation sequencing on preimplantation genetic testing for recurrent hydatidiform mole patients.<h4>Methods</h4>A total of ten recurrent hydatidiform mole patients aged 27-34 years with a history of at least twice hydatidiform moles and no normal pregnancy were collected from 2019 to 2020. The diagnosis of hydatidiform mole type was clarified using short tandem repeat genotyping on products of conception, and whole-exome sequencing was applied for all patients and their partners. Seven recurrent hydatidiform mole patients with complete hydatidiform mole/partial hydatidiform mole type among previous hydatidiform mole tissues and no Pathogenetic/Likely pathogenetic/Uncertain significance variants in NLRP7/KHDC3L/MEI1/C11orf80 underwent a pro2021-01-01T00:00:00Z2021 Nov2026-05-08T15:49:19.233Z2024-11-06T07:03:31.276ZS-EPMC86089483460857310.1007/s10815-021-02325-8