{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hostetler MA"],"funding":["National Cancer Institute","NCI NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2604-2611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8610019"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["Natural products are a bountiful source of bioactive molecules. Unfortunately, discovery of novel bioactive natural products is challenging due to cryptic biosynthetic gene clusters, low titers, and arduous purifications. Herein, we describe SNaPP (<u>S</u>ynthetic <u>Na</u>tural <u>P</u>roduct Inspired Cyclic <u>P</u>eptides), a method for identifying NP-inspired bioactive peptides. SNaPP expedites bioactive molecule discovery by combining bioinformatics predictions of nonribosomal peptide synthetases with chemical synthesis of the predicted natural products (pNPs). SNaPP utilizes a recently discovered cyclase, the penicillin binding protein-like cyclase, as the lynchpin for the development of a library of head-to-tail cyclic peptide pNPs. Analysis of 500 biosynthetic gene clusters allowe"],"journal":["ACS chemical biology"],"pubmed_title":["Synthetic Natural Product Inspired Cyclic Peptides."],"pmcid":["PMC8610019"],"funding_grant_id":["P30 CA023168","R35 GM138002","1R35GM138002-01"],"pubmed_authors":["Frerk A","Budimir Z","Smith C","Nelson S","Modi R","Hostetler MA","Gantt J","Woolsey I","Parkinson EI","Baker B"],"additional_accession":[]},"is_claimable":false,"name":"Synthetic Natural Product Inspired Cyclic Peptides.","description":"Natural products are a bountiful source of bioactive molecules. Unfortunately, discovery of novel bioactive natural products is challenging due to cryptic biosynthetic gene clusters, low titers, and arduous purifications. Herein, we describe SNaPP (<u>S</u>ynthetic <u>Na</u>tural <u>P</u>roduct Inspired Cyclic <u>P</u>eptides), a method for identifying NP-inspired bioactive peptides. SNaPP expedites bioactive molecule discovery by combining bioinformatics predictions of nonribosomal peptide synthetases with chemical synthesis of the predicted natural products (pNPs). SNaPP utilizes a recently discovered cyclase, the penicillin binding protein-like cyclase, as the lynchpin for the development of a library of head-to-tail cyclic peptide pNPs. Analysis of 500 biosynthetic gene clusters allowe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-07-14T15:04:32.704Z","creation":"2025-04-04T12:10:38.648Z"},"accession":"S-EPMC8610019","cross_references":{"pubmed":["34699170"],"doi":["10.1021/acschembio.1c00641"]}}