{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fujita A"],"funding":["HHS | NIH | National Institute of Mental Health","HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","NIMH NIH HHS","NIH HHS"],"pagination":["9539-9560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8612477"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(46)"],"pubmed_abstract":["The lateral hypothalamic area (LHA) is a highly conserved brain region critical for maintaining physiological homeostasis and goal-directed behavior. LHA neurons that express melanin-concentrating hormone (MCH) are key regulators of arousal, energy balance, and motivated behavior. However, cellular and functional diversity among LHA<sup>MCH</sup> neurons is not well understood. Previous anatomic and molecular data suggest that LHA<sup>MCH</sup> neurons may be parsed into at least two distinct subpopulations, one of which is enriched in neurokinin-3 receptor (NK3R), the receptor for neurokinin B (NKB), encoded by the <i>Tac2</i> gene. This tachykininergic ligand-receptor system has been implicated in reproduction, fear memory, and stress in other brain regions, but NKB interactions with LHA"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations."],"pmcid":["PMC8612477"],"funding_grant_id":["R01 DK118402","R01 MH112739","R01DK118402","R01MH112739","S10 OD016435"],"pubmed_authors":["Antony MS","Kanoski SE","Flynn WF","Fujita A","Mickelsen LE","Jackson AC","Zhong L","Chamiec-Case E"],"additional_accession":[]},"is_claimable":false,"name":"Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations.","description":"The lateral hypothalamic area (LHA) is a highly conserved brain region critical for maintaining physiological homeostasis and goal-directed behavior. LHA neurons that express melanin-concentrating hormone (MCH) are key regulators of arousal, energy balance, and motivated behavior. However, cellular and functional diversity among LHA<sup>MCH</sup> neurons is not well understood. Previous anatomic and molecular data suggest that LHA<sup>MCH</sup> neurons may be parsed into at least two distinct subpopulations, one of which is enriched in neurokinin-3 receptor (NK3R), the receptor for neurokinin B (NKB), encoded by the <i>Tac2</i> gene. This tachykininergic ligand-receptor system has been implicated in reproduction, fear memory, and stress in other brain regions, but NKB interactions with LHA","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T19:31:51.072Z","creation":"2025-02-19T02:58:13.483Z"},"accession":"S-EPMC8612477","cross_references":{"pubmed":["34642212"],"doi":["10.1523/jneurosci.2600-20.2021","10.1523/JNEUROSCI.2600-20.2021"]}}