biostudies-literatureUnknown9(4)Azizian AR<h4>Background</h4>There is an urgent need to inform decision-making and safe delivery of vaccines in a timely manner. Our objective is to describe the methods we used to perform a patient-oriented realist evaluation of COVID-19 vaccination implementation in Saskatchewan, Canada, in order to understand the underlying mechanisms and contexts of vaccination implementation and vaccine uptake.<h4>Methods</h4>This methodology paper describes a patient-oriented, realist, mixed-method evaluation to assess COVID-19 vaccination implementation in Regina, Saskatoon and Prince Albert, Saskatchewan. The study comprised 3 iterative phases guided by Realist And Meta-narrative Evidence Synthesis: Evolving Standards II (RAMESES II). In phase 1 (January-February 2021), we developed the initial program theorCMAJ openE1034-E1039https://www.ebi.ac.uk/biostudies/studies/S-EPMC8612651biostudies-literatureDeveloping a patient-oriented realist evaluation for COVID-19 vaccine implementation in Saskatchewan: a methodologic framework.PMC8612651Farthing GMuhajarine NSkrapek CCarr TGroot GVanstone JYasinian MAndreas BAzizian ARVerrall THartness CfalseDeveloping a patient-oriented realist evaluation for COVID-19 vaccine implementation in Saskatchewan: a methodologic framework.<h4>Background</h4>There is an urgent need to inform decision-making and safe delivery of vaccines in a timely manner. Our objective is to describe the methods we used to perform a patient-oriented realist evaluation of COVID-19 vaccination implementation in Saskatchewan, Canada, in order to understand the underlying mechanisms and contexts of vaccination implementation and vaccine uptake.<h4>Methods</h4>This methodology paper describes a patient-oriented, realist, mixed-method evaluation to assess COVID-19 vaccination implementation in Regina, Saskatoon and Prince Albert, Saskatchewan. The study comprised 3 iterative phases guided by Realist And Meta-narrative Evidence Synthesis: Evolving Standards II (RAMESES II). In phase 1 (January-February 2021), we developed the initial program theor2021-01-01T00:00:00Z2021 Oct-Dec2025-04-20T02:07:02.14Z2022-02-11T13:08:06.76ZS-EPMC86126513481525810.9778/cmajo.20210041